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10.1021/ml300241m http://scihub22266oqcxt.onion/10.1021/ml300241m C4025666!4025666 !24900424     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24900424 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2012 ; 3 (12 ): 1024-8 Nephropedia Template TP {{tp|p=24900424 |t=2012. SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington s Disease |pdf=|usr=}}{{24900424 }} gab.com Text SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington s Disease JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900424 #FOAvip We report a series of irreversible transglutaminase 2 inhibitors starting from a known lysine dipeptide bearing an acrylamide warhead. We established new SARs resulting in compounds demonstrating improved potency and better physical and calculated properties. Transglutaminase selectivity profiling and in vitro ADME properties of selected compounds are also reported. Twit Text FOAVip SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington s Disease ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900424 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900424 #FOAvip English Wikipedia <ref>{{Cite pmid|24900424 }}</ref> SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington s Disease #MMPMID24900424 Wityak J ; Prime ME ; Brookfield FA ; Courtney SM ; Erfan S ; Johnsen S ; Johnson PD ; Li M ; Marston RW ; Reed L ; Vaidya D ; Schaertl S ; Pedret-Dunn A ; Beconi M ; Macdonald D ; Muņoz-Sanjuan I ; Dominguez C ACS Med Chem Lett 2012[Dec]; 3 (12 ): 1024-8 PMID24900424 show ga We report a series of irreversible transglutaminase 2 inhibitors starting from a known lysine dipeptide bearing an acrylamide warhead. We established new SARs resulting in compounds demonstrating improved potency and better physical and calculated properties. Transglutaminase selectivity profiling and in vitro ADME properties of selected compounds are also reported. äSAR Development of Lysine-Based Irreversible Inhibitors of Transglutam(epmc).pdf DeepDyve Pubget Overpricing