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10.1021/ml300225h http://scihub22266oqcxt.onion/10.1021/ml300225h C4025665!4025665!24900389     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2012 ; 3 (10): 850-5 Nephropedia Template TP {{tp|p=24900389|t=2012. Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo |pdf=|usr=}}{{24900389}} gab.com Text Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900389 #FOAvip Optimization of a series of R132H IDH1 inhibitors from a high throughput screen led to the first potent molecules that show robust tumor 2-HG inhibition in a xenograft model. Compound 35 shows good potency in the U87 R132H cell based assay and ?90% tumor 2-HG inhibition in the corresponding mouse xenograft model following BID dosing. The magnitude and duration of tumor 2-HG inhibition correlates with free plasma concentration. Twit Text FOAVip Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900389 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900389 #FOAvip English Wikipedia <ref>{{Cite pmid|24900389}}</ref> Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo #MMPMID24900389 Popovici-Muller J; Saunders J; Salituro FG; Travins JM; Yan S; Zhao F; Gross S; Dang L; Yen KE; Yang H; Straley KS; Jin S; Kunii K; Fantin VR; Zhang S; Pan Q; Shi D; Biller SA; Su SM ACS Med Chem Lett 2012[Oct]; 3 (10): 850-5 PMID24900389show ga Optimization of a series of R132H IDH1 inhibitors from a high throughput screen led to the first potent molecules that show robust tumor 2-HG inhibition in a xenograft model. Compound 35 shows good potency in the U87 R132H cell based assay and ?90% tumor 2-HG inhibition in the corresponding mouse xenograft model following BID dosing. The magnitude and duration of tumor 2-HG inhibition correlates with free plasma concentration. äDiscovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tum(epmc).pdf DeepDyve Pubget Overpricing