Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1021/ml200250t http://scihub22266oqcxt.onion/10.1021/ml200250t C4025655!4025655 !24900450     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24900450 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2012 ; 3 (3 ): 198-202 Nephropedia Template TP {{tp|p=24900450 |t=2012. Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes |pdf=|usr=}}{{24900450 }} gab.com Text Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900450 #FOAvip A series of novel 2-piperidinopiperidine thiadiazoles were synthesized and evaluated as new leads of histamine H3 receptor antagonists. The 4-(5-([1,4'-bipiperidin]-1'-yl)-1,3,4-thiadiazol-2-yl)-2-(pyridin-2-yl)morpholine (5u) displayed excellent potency and ex vivo receptor occupancy. Compound 5u was also evaluated in vivo for antidiabetic efficacy in STZ diet-induced obesity type 2 diabetic mice for 2 or 12 days. Non-fasting glucose levels were significantly reduced as compared with vehicle-treated mice. In addition, 5u dose dependently blocked the increase of HbA1c after 12 days of treatment. Twit Text FOAVip Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900450 #FOAvip English Wikipedia <ref>{{Cite pmid|24900450 }}</ref> Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes #MMPMID24900450 Rao AU ; Shao N ; Aslanian RG ; Chan TY ; Degrado SJ ; Wang L ; McKittrick B ; Senior M ; West RE Jr ; Williams SM ; Wu RL ; Hwa J ; Patel B ; Zheng S ; Sondey C ; Palani A ACS Med Chem Lett 2012[Mar]; 3 (3 ): 198-202 PMID24900450 show ga A series of novel 2-piperidinopiperidine thiadiazoles were synthesized and evaluated as new leads of histamine H3 receptor antagonists. The 4-(5-([1,4'-bipiperidin]-1'-yl)-1,3,4-thiadiazol-2-yl)-2-(pyridin-2-yl)morpholine (5u) displayed excellent potency and ex vivo receptor occupancy. Compound 5u was also evaluated in vivo for antidiabetic efficacy in STZ diet-induced obesity type 2 diabetic mice for 2 or 12 days. Non-fasting glucose levels were significantly reduced as compared with vehicle-treated mice. In addition, 5u dose dependently blocked the increase of HbA1c after 12 days of treatment. äDiscovery of a potent thiadiazole class of histamine h3 receptor antag(epmc).pdf DeepDyve Pubget Overpricing