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10.1021/ml300144n http://scihub22266oqcxt.onion/10.1021/ml300144n C4025654!4025654!24900382     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2012 ; 3 (10): 793-8 Nephropedia Template TP {{tp|p=24900382|t=2012. Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11?-Hydroxysteroid Dehydrogenase Type 1 Inhibitors |pdf=|usr=}}{{24900382}} gab.com Text Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11 -Hydroxysteroid Dehydrogenase Type 1 Inhibitors JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900382 #FOAvip On the basis of scaffold hopping, a novel series of 2-alkyl-1-arylsulfonylprolinamides was discovered as 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD-1) inhibitors. A representative compound 4ek, obtained through SAR and structure optimization studies, demonstrates excellent in vitro potency against 11?-HSD-1 and dose-dependent in vivo inhibition of 11?-HSD-1 in a prednisone/prednisolone transformation biomarker study in mice. Twit Text FOAVip Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11 -Hydroxysteroid Dehydrogenase Type 1 Inhibitors ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900382 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900382 #FOAvip English Wikipedia <ref>{{Cite pmid|24900382}}</ref> Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11?-Hydroxysteroid Dehydrogenase Type 1 Inhibitors #MMPMID24900382 Yu J; Liu H; Xia G; Liu L; Xu Z; Chen Q; Ma C; Sun X; Xu J; Li H; Li P; Shi Y; Xiong B; Liu X; Shen J ACS Med Chem Lett 2012[Oct]; 3 (10): 793-8 PMID24900382show ga On the basis of scaffold hopping, a novel series of 2-alkyl-1-arylsulfonylprolinamides was discovered as 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD-1) inhibitors. A representative compound 4ek, obtained through SAR and structure optimization studies, demonstrates excellent in vitro potency against 11?-HSD-1 and dose-dependent in vivo inhibition of 11?-HSD-1 in a prednisone/prednisolone transformation biomarker study in mice. äDiscovery of 2-Alkyl-1-arylsulfonylprolinamides as 11?-Hydroxysteroid (epmc).pdf DeepDyve Pubget Overpricing