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10.1111/jnc.12613 http://scihub22266oqcxt.onion/10.1111/jnc.12613 C4024459!4024459!24261470     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurochem 2014 ; 129 (1): 60-71 Nephropedia Template TP {{tp|p=24261470|t=2014. N-NITROSOMELATONIN ENHANCES PHOTIC SYNCHRONIZATION OF MAMMALIAN CIRCADIAN RHYTHMS |pdf=|usr=}}{{24261470}} gab.com Text N-NITROSOMELATONIN ENHANCES PHOTIC SYNCHRONIZATION OF MAMMALIAN CIRCADIAN RHYTHMS JO: J Neurochem http://www.kidney.de/pget.php?&tw=1&pmid=24261470 #FOAvip Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a two-fold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of cFOS and PER1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-hour delay). Here we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. Twit Text FOAVip N-NITROSOMELATONIN ENHANCES PHOTIC SYNCHRONIZATION OF MAMMALIAN CIRCADIAN RHYTHMS ????J Neurochem http://www.kidney.de/pget.php?&tw=1&pmid=24261470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24261470 #FOAvip English Wikipedia <ref>{{Cite pmid|24261470}}</ref> N-NITROSOMELATONIN ENHANCES PHOTIC SYNCHRONIZATION OF MAMMALIAN CIRCADIAN RHYTHMS #MMPMID24261470 Baidanoff FM; Plano SA; Doctorovich F; Suárez SA; Golombek DA; Chiesa JJ J Neurochem 2014[Apr]; 129 (1): 60-71 PMID24261470show ga Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a two-fold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of cFOS and PER1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-hour delay). Here we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. äN-NITROSOMELATONIN ENHANCES PHOTIC SYNCHRONIZATION OF MAMMALIAN CIRCAD(epmc).pdf DeepDyve Pubget Overpricing