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10.1093/bioinformatics/btt687 http://scihub22266oqcxt.onion/10.1093/bioinformatics/btt687 C4023302!4023302 !24292935     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24292935 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Bioinformatics 2014 ; 30 (3 ): 360-8 Nephropedia Template TP {{tp|p=24292935 |t=2014. Gene Sets Net Correlations Analysis (GSNCA): a multivariate differential coexpression test for gene sets |pdf=|usr=}}{{24292935 }} gab.com Text Gene Sets Net Correlations Analysis (GSNCA): a multivariate differential coexpression test for gene sets JO: Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=24292935 #FOAvip MOTIVATION: To date, gene set analysis approaches primarily focus on identifying differentially expressed gene sets (pathways). Methods for identifying differentially coexpressed pathways also exist but are mostly based on aggregated pairwise correlations or other pairwise measures of coexpression. Instead, we propose Gene Sets Net Correlations Analysis (GSNCA), a multivariate differential coexpression test that accounts for the complete correlation structure between genes. RESULTS: In GSNCA, weight factors are assigned to genes in proportion to the genes' cross-correlations (intergene correlations). The problem of finding the weight vectors is formulated as an eigenvector problem with a unique solution. GSNCA tests the null hypothesis that for a gene set there is no difference in the weight vectors of the genes between two conditions. In simulation studies and the analyses of experimental data, we demonstrate that GSNCA captures changes in the structure of genes' cross-correlations rather than differences in the averaged pairwise correlations. Thus, GSNCA infers differences in coexpression networks, however, bypassing method-dependent steps of network inference. As an additional result from GSNCA, we define hub genes as genes with the largest weights and show that these genes correspond frequently to major and specific pathway regulators, as well as to genes that are most affected by the biological difference between two conditions. In summary, GSNCA is a new approach for the analysis of differentially coexpressed pathways that also evaluates the importance of the genes in the pathways, thus providing unique information that may result in the generation of novel biological hypotheses. AVAILABILITY AND IMPLEMENTATION: Implementation of the GSNCA test in R is available upon request from the authors. Twit Text FOAVip Gene Sets Net Correlations Analysis (GSNCA): a multivariate differential coexpression test for gene sets ????Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=24292935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24292935 #FOAvip English Wikipedia <ref>{{Cite pmid|24292935 }}</ref> Gene Sets Net Correlations Analysis (GSNCA): a multivariate differential coexpression test for gene sets #MMPMID24292935 Rahmatallah Y ; Emmert-Streib F ; Glazko G Bioinformatics 2014[Feb]; 30 (3 ): 360-8 PMID24292935 show ga MOTIVATION: To date, gene set analysis approaches primarily focus on identifying differentially expressed gene sets (pathways). Methods for identifying differentially coexpressed pathways also exist but are mostly based on aggregated pairwise correlations or other pairwise measures of coexpression. Instead, we propose Gene Sets Net Correlations Analysis (GSNCA), a multivariate differential coexpression test that accounts for the complete correlation structure between genes. RESULTS: In GSNCA, weight factors are assigned to genes in proportion to the genes' cross-correlations (intergene correlations). The problem of finding the weight vectors is formulated as an eigenvector problem with a unique solution. GSNCA tests the null hypothesis that for a gene set there is no difference in the weight vectors of the genes between two conditions. In simulation studies and the analyses of experimental data, we demonstrate that GSNCA captures changes in the structure of genes' cross-correlations rather than differences in the averaged pairwise correlations. Thus, GSNCA infers differences in coexpression networks, however, bypassing method-dependent steps of network inference. As an additional result from GSNCA, we define hub genes as genes with the largest weights and show that these genes correspond frequently to major and specific pathway regulators, as well as to genes that are most affected by the biological difference between two conditions. In summary, GSNCA is a new approach for the analysis of differentially coexpressed pathways that also evaluates the importance of the genes in the pathways, thus providing unique information that may result in the generation of novel biological hypotheses. AVAILABILITY AND IMPLEMENTATION: Implementation of the GSNCA test in R is available upon request from the authors. |*Gene Regulatory Networks [MESH] |Cell Line, Tumor [MESH] |Gene Expression Profiling/*methods [MESH] |Genes, p53 [MESH] |Humans [MESH] |Multivariate Analysis [MESH]Gene Sets Net Correlations Analysis (GSNCA): a multivariate differenti(epmc).pdf DeepDyve Pubget Overpricing