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10.1016/j.tcb.2013.10.005

http://scihub22266oqcxt.onion/10.1016/j.tcb.2013.10.005
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C4022146!4022146!24239163
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suck abstract from ncbi


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pmid24239163      Trends+Cell+Biol 2014 ; 24 (4): 230-7
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  • Compensatory Cellular Hypertrophy: The Other Strategy for Tissue Homeostasis #MMPMID24239163
  • Tamori Y; Deng WM
  • Trends Cell Biol 2014[Apr]; 24 (4): 230-7 PMID24239163show ga
  • Metazoan tissues have the ability to maintain tissue size and morphology while eliminating aberrant or damaged cells. In the tissue homeostasis system, cell division is the primary strategy cells use not only to increase tissue size during development but also to compensate for cell loss in tissue repair. Recent studies in Drosophila, however, have shown that cells in post-mitotic tissues undergo hypertrophic growth without division, contributing to tissue repair as well as organ development. Indeed, similar compensatory cellular hypertrophy (CCH) can be observed in different contexts such as mammalian hepatocytes or corneal endothelial cells. Here we highlight these findings and discuss the underlying mechanisms of CCH, which is likely an evolutionarily conserved strategy for homeostatic tissue growth in metazoans.
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