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Sleep, plasticity and the pathophysiology of neurodevelopmental disorders: the
potential roles of protein synthesis and other cellular processes
#MMPMID24839550
Picchioni D
; Reith RM
; Nadel JL
; Smith CB
Brain Sci
2014[Mar]; 4
(1
): 150-201
PMID24839550
show ga
Sleep is important for neural plasticity, and plasticity underlies
sleep-dependent memory consolidation. It is widely appreciated that protein
synthesis plays an essential role in neural plasticity. Studies of
sleep-dependent memory and sleep-dependent plasticity have begun to examine
alterations in these functions in populations with neurological and psychiatric
disorders. Such an approach acknowledges that disordered sleep may have
functional consequences during wakefulness. Although neurodevelopmental disorders
are not considered to be sleep disorders per se, recent data has revealed that
sleep abnormalities are among the most prevalent and common symptoms and may
contribute to the progression of these disorders. The main goal of this review is
to highlight the role of disordered sleep in the pathology of neurodevelopmental
disorders and to examine some potential mechanisms by which sleep-dependent
plasticity may be altered. We will also briefly attempt to extend the same logic
to the other end of the developmental spectrum and describe a potential role of
disordered sleep in the pathology of neurodegenerative diseases. We conclude by
discussing ongoing studies that might provide a more integrative approach to the
study of sleep, plasticity, and neurodevelopmental disorders.
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