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10.1016/j.jbi.2013.11.002

http://scihub22266oqcxt.onion/10.1016/j.jbi.2013.11.002
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suck abstract from ncbi


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pmid24239612      J+Biomed+Inform 2014 ; 52 (ä): 78-91
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  • The Ontology of Clinical Research (OCRe): An Informatics Foundation for the Science of Clinical Research #MMPMID24239612
  • Sim I; Tu SW; Carini S; Lehmann HP; Pollock BH; Peleg M; Wittkowski KM
  • J Biomed Inform 2014[Dec]; 52 (ä): 78-91 PMID24239612show ga
  • To date, the scientific process for generating, interpreting, and applying knowledge has received less informatics attention than operational processes for conducting clinical studies. The activities of these scientific processes ? the science of clinical research ? are centered on the study protocol, which is the abstract representation of the scientific design of a clinical study. The Ontology of Clinical Research (OCRe) is an OWL 2 model of the entities and relationships of study design protocols for the purpose of computationally supporting the design and analysis of human studies. OCRe?s modeling is independent of any specific study design or clinical domain. It includes a study design typology and a specialized module called ERGO Annotation for capturing the meaning of eligibility criteria. In this paper, we describe the key informatics use cases of each phase of a study?s scientific lifecycle, present OCRe and the principles behind its modeling, and describe applications of OCRe and associated technologies to a range of clinical research use cases. OCRe captures the central semantics that underlies the scientific processes of clinical research and can serve as an informatics foundation for supporting the entire range of knowledge activities that constitute the science of clinical research.
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