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2014 ; 52
(ä): 78-91
Nephropedia Template TP
gab.com Text
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English Wikipedia
The Ontology of Clinical Research (OCRe): an informatics foundation for the
science of clinical research
#MMPMID24239612
Sim I
; Tu SW
; Carini S
; Lehmann HP
; Pollock BH
; Peleg M
; Wittkowski KM
J Biomed Inform
2014[Dec]; 52
(ä): 78-91
PMID24239612
show ga
To date, the scientific process for generating, interpreting, and applying
knowledge has received less informatics attention than operational processes for
conducting clinical studies. The activities of these scientific processes - the
science of clinical research - are centered on the study protocol, which is the
abstract representation of the scientific design of a clinical study. The
Ontology of Clinical Research (OCRe) is an OWL 2 model of the entities and
relationships of study design protocols for the purpose of computationally
supporting the design and analysis of human studies. OCRe's modeling is
independent of any specific study design or clinical domain. It includes a study
design typology and a specialized module called ERGO Annotation for capturing the
meaning of eligibility criteria. In this paper, we describe the key informatics
use cases of each phase of a study's scientific lifecycle, present OCRe and the
principles behind its modeling, and describe applications of OCRe and associated
technologies to a range of clinical research use cases. OCRe captures the central
semantics that underlies the scientific processes of clinical research and can
serve as an informatics foundation for supporting the entire range of knowledge
activities that constitute the science of clinical research.