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10.1016/j.addr.2013.11.011 http://scihub22266oqcxt.onion/10.1016/j.addr.2013.11.011 C4019703!4019703!24309015     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24309015&cmd=llinks): Failed to open stream: HTTP request failed! 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In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer |pdf=|usr=}}{{24309015}} gab.com Text In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=24309015 #FOAvip Tumor-stroma interactions have emerged as critical determinants of drug efficacy. However, the underlying biological and physicochemical mechanisms by which the microenvironment regulates therapeutic response remain unclear, due in part to a lack of physiologically relevant in vitro platforms to accurately interrogate tissue-level phenomena. Tissue-engineered tumor models are beginning to address this shortcoming. By allowing selective incorporation of microenvironmental complexity, these platforms afford unique access to tumor-associated signaling and transport dynamics. This review will focus on engineering approaches to study drug delivery as a function of tumor-associated changes of the vasculature and extracellular matrix (ECM). First, we review current biological understanding of these components and discuss their impact on transport processes. Then, we evaluate existing microfluidic, tissue engineering, and materials science strategies to recapitulate vascular and ECM characteristics of tumors, and finish by outlining challenges and future directions of the field that may ultimately improve anti-cancer therapies. Twit Text FOAVip In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=24309015 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24309015 #FOAvip English Wikipedia <ref>{{Cite pmid|24309015}}</ref> In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer #MMPMID24309015 Seo BR; DelNero P; Fischbach C Adv Drug Deliv Rev 2014[Apr]; ä (ä): 205-16 PMID24309015show ga Tumor-stroma interactions have emerged as critical determinants of drug efficacy. However, the underlying biological and physicochemical mechanisms by which the microenvironment regulates therapeutic response remain unclear, due in part to a lack of physiologically relevant in vitro platforms to accurately interrogate tissue-level phenomena. Tissue-engineered tumor models are beginning to address this shortcoming. By allowing selective incorporation of microenvironmental complexity, these platforms afford unique access to tumor-associated signaling and transport dynamics. This review will focus on engineering approaches to study drug delivery as a function of tumor-associated changes of the vasculature and extracellular matrix (ECM). First, we review current biological understanding of these components and discuss their impact on transport processes. Then, we evaluate existing microfluidic, tissue engineering, and materials science strategies to recapitulate vascular and ECM characteristics of tumors, and finish by outlining challenges and future directions of the field that may ultimately improve anti-cancer therapies. äIn vitro models of tumor vessels and matrix: Engineering approaches to(epmc).pdf DeepDyve Pubget Overpricing