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10.1021/ml2001938 http://scihub22266oqcxt.onion/10.1021/ml2001938 C4018152!4018152 !24900281     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24900281 &cmd=llinks): Failed to open stream: HTTP request failed! 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Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats |pdf=|usr=}}{{24900281 }} gab.com Text Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900281 #FOAvip l-2-Hydroxy acid oxidase (Hao2) is a peroxisomal enzyme with predominant expression in the liver and kidney. Hao2 was recently identified as a candidate gene for blood pressure quantitative trait locus in rats. To investigate a pharmacological role of Hao2 in the management of blood pressure, selective Hao2 inhibitors were developed. Optimization of screening hits 1 and 2 led to the discovery of compounds 3 and 4 as potent and selective rat Hao2 inhibitors with pharmacokinetic properties suitable for in vivo studies in rats. Treatment with compound 3 or 4 resulted in a significant reduction or attenuation of blood pressure in an established or developing model of hypertension, deoxycorticosterone acetate-treated rats. This is the first report demonstrating a pharmacological benefit of selective Hao2 inhibitors in a relevant model of hypertension. Twit Text FOAVip Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900281 #FOAvip English Wikipedia <ref>{{Cite pmid|24900281 }}</ref> Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats #MMPMID24900281 Barawkar DA ; Meru A ; Bandyopadhyay A ; Banerjee A ; Deshpande AM ; Athare C ; Koduru C ; Khose G ; Gundu J ; Mahajan K ; Patil P ; Kandalkar SR ; Niranjan S ; Bhosale S ; De S ; Mukhopadhyay S ; Chaudhary S ; Koul S ; Singh U ; Chugh A ; Palle VP ; Mookhtiar KA ; Vacca J ; Chakravarty PK ; Nargund RP ; Wright SD ; Roy S ; Graziano MP ; Singh SB ; Cully D ; Cai TQ ACS Med Chem Lett 2011[Dec]; 2 (12 ): 919-23 PMID24900281 show ga l-2-Hydroxy acid oxidase (Hao2) is a peroxisomal enzyme with predominant expression in the liver and kidney. Hao2 was recently identified as a candidate gene for blood pressure quantitative trait locus in rats. To investigate a pharmacological role of Hao2 in the management of blood pressure, selective Hao2 inhibitors were developed. Optimization of screening hits 1 and 2 led to the discovery of compounds 3 and 4 as potent and selective rat Hao2 inhibitors with pharmacokinetic properties suitable for in vivo studies in rats. Treatment with compound 3 or 4 resulted in a significant reduction or attenuation of blood pressure in an established or developing model of hypertension, deoxycorticosterone acetate-treated rats. This is the first report demonstrating a pharmacological benefit of selective Hao2 inhibitors in a relevant model of hypertension. äPotent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase(epmc).pdf DeepDyve Pubget Overpricing