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10.1021/ml100228m http://scihub22266oqcxt.onion/10.1021/ml100228m C4018108!4018108 !24900287     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24900287 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2011 ; 2 (2 ): 102-6 Nephropedia Template TP {{tp|p=24900287 |t=2011. Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1) |pdf=|usr=}}{{24900287 }} gab.com Text Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1) JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900287 #FOAvip Optimization of a benzofuranyl S1P1 agonist lead compound (3) led to the discovery of 1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid (14), a potent S1P1 agonist with minimal activity at S1P3. Dosed orally at 0.3 mg/kg, 14 significantly reduced blood lymphocyte counts 24 h postdose and attenuated a delayed type hypersensitivity (DTH) response to antigen challenge. Twit Text FOAVip Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1) ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900287 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900287 #FOAvip English Wikipedia <ref>{{Cite pmid|24900287 }}</ref> Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1) #MMPMID24900287 Lanman BA ; Cee VJ ; Cheruku SR ; Frohn M ; Golden J ; Lin J ; Lobera M ; Marantz Y ; Muller KM ; Neira SC ; Pickrell AJ ; Rivenzon-Segal D ; Schutz N ; Sharadendu A ; Yu X ; Zhang Z ; Buys J ; Fiorino M ; Gore A ; Horner M ; Itano A ; McElvain M ; Middleton S ; Schrag M ; Vargas HM ; Xu H ; Xu Y ; Zhang X ; Siu J ; Bürli RW ACS Med Chem Lett 2011[Feb]; 2 (2 ): 102-6 PMID24900287 show ga Optimization of a benzofuranyl S1P1 agonist lead compound (3) led to the discovery of 1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid (14), a potent S1P1 agonist with minimal activity at S1P3. Dosed orally at 0.3 mg/kg, 14 significantly reduced blood lymphocyte counts 24 h postdose and attenuated a delayed type hypersensitivity (DTH) response to antigen challenge. äDiscovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingo(epmc).pdf DeepDyve Pubget Overpricing