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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Med+Chem+Lett 2011 ; 2 (11): 828-33 Nephropedia Template TP
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Type 1 Phototherapeutic Agents, Part I: Preparation and Cancer Cell Viability Studies of Novel Photolabile Sulfenamides #MMPMID24900271
Karwa AS; Poreddy AR; Asmelash B; Lin TS; Dorshow RB; Rajagopalan R
ACS Med Chem Lett 2011[Nov]; 2 (11): 828-33 PMID24900271show ga
Novel type 1 phototherapeutic agents based on compounds containing S?N bonds (sulfenamides) were synthesized, assessed for free radical generation, and evaluated in vitro for cell death efficacy in four cancer cell lines (U937, HTC11, KB, and HT29). All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV-B light, as determined by electron spin resonance spectroscopy. Among the sulfenamides, the most potent compounds were derived from dibenzazepine 7b and dihydroacridine 8b as determined in all of the four cancer cell lines.