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10.1021/ml2001483

http://scihub22266oqcxt.onion/10.1021/ml2001483
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C4018100!4018100!24900271
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suck abstract from ncbi


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pmid24900271      ACS+Med+Chem+Lett 2011 ; 2 (11): 828-33
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  • Type 1 Phototherapeutic Agents, Part I: Preparation and Cancer Cell Viability Studies of Novel Photolabile Sulfenamides #MMPMID24900271
  • Karwa AS; Poreddy AR; Asmelash B; Lin TS; Dorshow RB; Rajagopalan R
  • ACS Med Chem Lett 2011[Nov]; 2 (11): 828-33 PMID24900271show ga
  • Novel type 1 phototherapeutic agents based on compounds containing S?N bonds (sulfenamides) were synthesized, assessed for free radical generation, and evaluated in vitro for cell death efficacy in four cancer cell lines (U937, HTC11, KB, and HT29). All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV-B light, as determined by electron spin resonance spectroscopy. Among the sulfenamides, the most potent compounds were derived from dibenzazepine 7b and dihydroacridine 8b as determined in all of the four cancer cell lines.
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