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2011 ; 2
(11
): 828-33
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Type 1 phototherapeutic agents, part I: preparation and cancer cell viability
studies of novel photolabile sulfenamides
#MMPMID24900271
Karwa AS
; Poreddy AR
; Asmelash B
; Lin TS
; Dorshow RB
; Rajagopalan R
ACS Med Chem Lett
2011[Nov]; 2
(11
): 828-33
PMID24900271
show ga
Novel type 1 phototherapeutic agents based on compounds containing S-N bonds
(sulfenamides) were synthesized, assessed for free radical generation, and
evaluated in vitro for cell death efficacy in four cancer cell lines (U937,
HTC11, KB, and HT29). All of the compounds were found to produce copious free
radicals upon photoexcitation with UV-A and/or UV-B light, as determined by
electron spin resonance spectroscopy. Among the sulfenamides, the most potent
compounds were derived from dibenzazepine 7b and dihydroacridine 8b as determined
in all of the four cancer cell lines.