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10.1021/ml1002234 http://scihub22266oqcxt.onion/10.1021/ml1002234 C4018074!4018074!24900313     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2011 ; 2 (5): 326-30 Nephropedia Template TP {{tp|p=24900313|t=2011. Discovery of AMG 853, a CRTH2 and DP Dual Antagonist |pdf=|usr=}}{{24900313}} gab.com Text Discovery of AMG 853, a CRTH2 and DP Dual Antagonist JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900313 #FOAvip Prostaglandin D2 (PGD2) plays a key role in mediating allergic reactions seen in asthma, allergic rhinitis, and atopic dermatitis. PGD2 exerts its activity through two G protein-coupled receptors (GPCRs), prostanoid D receptor (DP or DP1), and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2 or DP2). We report the optimization of a series of phenylacetic acid derivatives in an effort to improve the dual activity of AMG 009 against DP and CRTH2. These efforts led to the discovery of AMG 853 (2-(4-(4-(tert-butylcarbamoyl)-2-(2-chloro-4-cyclopropylphenyl sulfonamido)phenoxy)-5-chloro-2-fluorophenyl)acetic acid), which is being evaluated in human clinical trials for asthma. Twit Text FOAVip Discovery of AMG 853, a CRTH2 and DP Dual Antagonist ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900313 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900313 #FOAvip English Wikipedia <ref>{{Cite pmid|24900313}}</ref> Discovery of AMG 853, a CRTH2 and DP Dual Antagonist #MMPMID24900313 Liu J; Li AR; Wang Y; Johnson MG; Su Y; Shen W; Wang X; Lively S; Brown M; Lai S; Gonzalez Lopez De Turiso F; Xu Q; Van Lengerich B; Schmitt M; Fu Z; Sun Y; Lawlis S; Seitz L; Danao J; Wait J; Ye Q; Tang HL; Grillo M; Collins TL; Sullivan TJ; Medina JC ACS Med Chem Lett 2011[May]; 2 (5): 326-30 PMID24900313show ga Prostaglandin D2 (PGD2) plays a key role in mediating allergic reactions seen in asthma, allergic rhinitis, and atopic dermatitis. PGD2 exerts its activity through two G protein-coupled receptors (GPCRs), prostanoid D receptor (DP or DP1), and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2 or DP2). We report the optimization of a series of phenylacetic acid derivatives in an effort to improve the dual activity of AMG 009 against DP and CRTH2. These efforts led to the discovery of AMG 853 (2-(4-(4-(tert-butylcarbamoyl)-2-(2-chloro-4-cyclopropylphenyl sulfonamido)phenoxy)-5-chloro-2-fluorophenyl)acetic acid), which is being evaluated in human clinical trials for asthma. äDiscovery of AMG 853, a CRTH2 and DP Dual Antagonist (epmc).pdf DeepDyve Pubget Overpricing