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10.1021/ml100251u http://scihub22266oqcxt.onion/10.1021/ml100251u C4017979!4017979!24900295     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2011 ; 2 (2): 171-6 Nephropedia Template TP {{tp|p=24900295|t=2011. Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia |pdf=|usr=}}{{24900295}} gab.com Text Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900295 #FOAvip Nicotinic acid has been used clinically for decades to control serum lipoproteins. Nicotinic acid lowers very low-density lipoprotein (VLDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, and lipoprotein-a (LPa), and it is also effective in raising high-density lipoprotein (HDL)-cholesterol. However, nicotinic acid has several side effects in clinical use. The most notable is intense cutaneous vasodilation ?flushing? on the upper body and face. We discovered a pyranopyrimidinedione series to be nicotinic acid receptor agonists. A potent nicotinic acid receptor agonist from this series {5-(3-cyclopropylpropyl)-2-(difluoromethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione} with reduced flushing side effect in dogs was identified. Twit Text FOAVip Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900295 #FOAvip English Wikipedia <ref>{{Cite pmid|24900295}}</ref> Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia #MMPMID24900295 Qin J; Rao A; Chen X; Zhu X; Liu Z; Huang X; Degrado S; Huang Y; Xiao D; Aslanian R; Cheewatrakoolpong B; Zhang H; Greenfeder S; Farley C; Cook J; Kurowski S; Li Q; van Heek M; Chintala M; Wang G; Hsieh Y; Li F; Palani A ACS Med Chem Lett 2011[Feb]; 2 (2): 171-6 PMID24900295show ga Nicotinic acid has been used clinically for decades to control serum lipoproteins. Nicotinic acid lowers very low-density lipoprotein (VLDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, and lipoprotein-a (LPa), and it is also effective in raising high-density lipoprotein (HDL)-cholesterol. However, nicotinic acid has several side effects in clinical use. The most notable is intense cutaneous vasodilation ?flushing? on the upper body and face. We discovered a pyranopyrimidinedione series to be nicotinic acid receptor agonists. A potent nicotinic acid receptor agonist from this series {5-(3-cyclopropylpropyl)-2-(difluoromethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione} with reduced flushing side effect in dogs was identified. äDiscovery of a Potent Nicotinic Acid Receptor Agonist for the Treatmen(epmc).pdf DeepDyve Pubget Overpricing