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10.1021/ja501285s http://scihub22266oqcxt.onion/10.1021/ja501285s C4017609!4017609!24754228     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Chem+Soc 2014 ; 136 (18): 6562-5 Nephropedia Template TP {{tp|p=24754228|t=2014. DNA Damage by Histone Radicals in Nucleosome Core Particles |pdf=|usr=}}{{24754228}} gab.com Text DNA Damage by Histone Radicals in Nucleosome Core Particles JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=24754228 #FOAvip Although DNA binding proteins shield the genetic material from diffusible reactive oxygen species by reacting with them, the resulting protein (peroxyl) radicals can oxidize the bound DNA. To explore this possible DNA damage by protein radicals, histone H4 proteins containing an azoalkane radical precursor at defined sites were prepared. Photolysis of a nucleosome core particle containing the modified protein produces DNA damage that is consistent with selective C4?-oxidation. The nucleotide(s) damaged is highly dependent on proximity to the protein radical. These experiments provide insight into the effects of oxidative stress on protein-bound DNA, revealing an additional layer of complexity concerning nucleic acid damage. Twit Text FOAVip DNA Damage by Histone Radicals in Nucleosome Core Particles ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=24754228 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24754228 #FOAvip English Wikipedia <ref>{{Cite pmid|24754228}}</ref> DNA Damage by Histone Radicals in Nucleosome Core Particles #MMPMID24754228 Zhou C; Greenberg MM J Am Chem Soc 2014[May]; 136 (18): 6562-5 PMID24754228show ga Although DNA binding proteins shield the genetic material from diffusible reactive oxygen species by reacting with them, the resulting protein (peroxyl) radicals can oxidize the bound DNA. To explore this possible DNA damage by protein radicals, histone H4 proteins containing an azoalkane radical precursor at defined sites were prepared. Photolysis of a nucleosome core particle containing the modified protein produces DNA damage that is consistent with selective C4?-oxidation. The nucleotide(s) damaged is highly dependent on proximity to the protein radical. These experiments provide insight into the effects of oxidative stress on protein-bound DNA, revealing an additional layer of complexity concerning nucleic acid damage. äDNA Damage by Histone Radicals in Nucleosome Core Particles (epmc).pdf DeepDyve Pubget Overpricing