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10.1155/2014/746979

http://scihub22266oqcxt.onion/10.1155/2014/746979
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C4016856!4016856!24895499
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suck abstract from ncbi


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pmid24895499      Comput+Math+Methods+Med 2014 ; 2014 (ä): ä
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  • Establishing Reliable miRNA-Cancer Association Network Based on Text-Mining Method #MMPMID24895499
  • Li L; Hu X; Yang Z; Jia Z; Fang M; Zhang L; Zhou Y
  • Comput Math Methods Med 2014[]; 2014 (ä): ä PMID24895499show ga
  • Associating microRNAs (miRNAs) with cancers is an important step of understanding the mechanisms of cancer pathogenesis and finding novel biomarkers for cancer therapies. In this study, we constructed a miRNA-cancer association network (miCancerna) based on more than 1,000 miRNA-cancer associations detected from millions of abstracts with the text-mining method, including 226 miRNA families and 20 common cancers. We further prioritized cancer-related miRNAs at the network level with the random-walk algorithm, achieving a relatively higher performance than previous miRNA disease networks. Finally, we examined the top 5 candidate miRNAs for each kind of cancer and found that 71% of them are confirmed experimentally. miCancerna would be an alternative resource for the cancer-related miRNA identification.
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