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10.1177/1933719113512532

http://scihub22266oqcxt.onion/10.1177/1933719113512532
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C4016723!4016723!24336677
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suck abstract from ncbi


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pmid24336677      Reprod+Sci 2014 ; 21 (6): 754-60
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  • First-Trimester Levels of Pregnancy-Associated Plasma Protein A2 (PAPP-A2) in the Maternal Circulation Are Elevated in Pregnancies That Subsequently Develop Preeclampsia #MMPMID24336677
  • Crosley EJ; Durland U; Seethram K; MacRae S; Gruslin A; Christians JK
  • Reprod Sci 2014[Jun]; 21 (6): 754-60 PMID24336677show ga
  • Recent studies have consistently found pregnancy-associated plasma protein A2 (PAPP-A2) to be upregulated in preeclamptic placentae at term. We tested whether first-trimester circulating PAPP-A2 levels differed between complicated and uncomplicated pregnancies. We measured maternal PAPP-A2 levels at 10 to 14 weeks of gestational age in 17 pregnancies resulting in small-for-gestational-age (SGA) infants, 6 which developed preeclampsia (PE), 1 which developed PE and resulted in an SGA infant, and 37 gestational age-matched controls. The concentration of the PAPP-A2 isoform corresponding to the full-length protein was significantly higher in pregnancies that developed PE (35 ng/mL) compared with those that did not (23 ng/mL; P < .044). In contrast, we found no difference in PAPP-A2 levels between pregnancies that did or did not result in an SGA infant. The upregulation of PAPP-A2 that has previously been observed in PE at term appears to begin early in pregnancy, well before the symptoms develop.
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