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10.1177/1933719113512532

http://scihub22266oqcxt.onion/10.1177/1933719113512532
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suck abstract from ncbi


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pmid24336677
      Reprod+Sci 2014 ; 21 (6 ): 754-60
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  • First-trimester levels of pregnancy-associated plasma protein A2 (PAPP-A2) in the maternal circulation are elevated in pregnancies that subsequently develop preeclampsia #MMPMID24336677
  • Crosley EJ ; Durland U ; Seethram K ; MacRae S ; Gruslin A ; Christians JK
  • Reprod Sci 2014[Jun]; 21 (6 ): 754-60 PMID24336677 show ga
  • Recent studies have consistently found pregnancy-associated plasma protein A2 (PAPP-A2) to be upregulated in preeclamptic placentae at term. We tested whether first-trimester circulating PAPP-A2 levels differed between complicated and uncomplicated pregnancies. We measured maternal PAPP-A2 levels at 10 to 14 weeks of gestational age in 17 pregnancies resulting in small-for-gestational-age (SGA) infants, 6 which developed preeclampsia (PE), 1 which developed PE and resulted in an SGA infant, and 37 gestational age-matched controls. The concentration of the PAPP-A2 isoform corresponding to the full-length protein was significantly higher in pregnancies that developed PE (35 ng/mL) compared with those that did not (23 ng/mL; P < .044). In contrast, we found no difference in PAPP-A2 levels between pregnancies that did or did not result in an SGA infant. The upregulation of PAPP-A2 that has previously been observed in PE at term appears to begin early in pregnancy, well before the symptoms develop.
  • |Adult [MESH]
  • |Biomarkers/blood [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Placental Circulation/*physiology [MESH]
  • |Pre-Eclampsia/*blood/*diagnosis [MESH]
  • |Pregnancy [MESH]
  • |Pregnancy Trimester, First/*blood [MESH]
  • |Pregnancy-Associated Plasma Protein-A/*biosynthesis [MESH]


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