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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Reprod+Sci
2014 ; 21
(6
): 754-60
Nephropedia Template TP
gab.com Text
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English Wikipedia
First-trimester levels of pregnancy-associated plasma protein A2 (PAPP-A2) in the
maternal circulation are elevated in pregnancies that subsequently develop
preeclampsia
#MMPMID24336677
Crosley EJ
; Durland U
; Seethram K
; MacRae S
; Gruslin A
; Christians JK
Reprod Sci
2014[Jun]; 21
(6
): 754-60
PMID24336677
show ga
Recent studies have consistently found pregnancy-associated plasma protein A2
(PAPP-A2) to be upregulated in preeclamptic placentae at term. We tested whether
first-trimester circulating PAPP-A2 levels differed between complicated and
uncomplicated pregnancies. We measured maternal PAPP-A2 levels at 10 to 14 weeks
of gestational age in 17 pregnancies resulting in small-for-gestational-age (SGA)
infants, 6 which developed preeclampsia (PE), 1 which developed PE and resulted
in an SGA infant, and 37 gestational age-matched controls. The concentration of
the PAPP-A2 isoform corresponding to the full-length protein was significantly
higher in pregnancies that developed PE (35 ng/mL) compared with those that did
not (23 ng/mL; P < .044). In contrast, we found no difference in PAPP-A2 levels
between pregnancies that did or did not result in an SGA infant. The upregulation
of PAPP-A2 that has previously been observed in PE at term appears to begin early
in pregnancy, well before the symptoms develop.