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10.1016/j.cell.2014.02.018 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.02.018 C4015189!4015189!24725408     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 157 (2): 420-32 Nephropedia Template TP {{tp|p=24725408|t=2014. Asymmetric friction of non-motor MAPs can lead to their directional motion in active microtubule networks |pdf=|usr=}}{{24725408}} gab.com Text Asymmetric friction of non-motor MAPs can lead to their directional motion in active microtubule networks JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24725408 #FOAvip Diverse cellular processes require microtubules to be organized into distinct structures, such as asters or bundles. Within these dynamic motifs, microtubule-associated proteins (MAPs) are frequently under load, but how force modulates these proteins? function is poorly understood. Here, we combine optical-trapping with TIRF-based microscopy to measure the force-dependence of microtubule interaction for three non-motor MAPs (NuMA, PRC1, and EB1) required for cell division. We find that frictional forces increase non-linearly with MAP velocity across microtubules and depend on filament polarity, with NuMA?s friction being lower when moving towards minus-ends, EB1?s lower towards plus-ends, and PRC1 exhibiting no directional preference. Mathematical models predict, and experiments confirm, that MAPs with asymmetric friction can move directionally within active microtubule pairs they crosslink. Our findings reveal how non-motor MAPs can generate frictional resistance in dynamic cytoskeletal networks via micromechanical adaptations whose anisotropy may be optimized for MAP localization and function within cellular structures. Twit Text FOAVip Asymmetric friction of non-motor MAPs can lead to their directional motion in active microtubule networks ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24725408 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24725408 #FOAvip English Wikipedia <ref>{{Cite pmid|24725408}}</ref> Asymmetric friction of non-motor MAPs can lead to their directional motion in active microtubule networks #MMPMID24725408 Forth S; Hsia KC; Shimamoto Y; Kapoor TM Cell 2014[Apr]; 157 (2): 420-32 PMID24725408show ga Diverse cellular processes require microtubules to be organized into distinct structures, such as asters or bundles. Within these dynamic motifs, microtubule-associated proteins (MAPs) are frequently under load, but how force modulates these proteins? function is poorly understood. Here, we combine optical-trapping with TIRF-based microscopy to measure the force-dependence of microtubule interaction for three non-motor MAPs (NuMA, PRC1, and EB1) required for cell division. We find that frictional forces increase non-linearly with MAP velocity across microtubules and depend on filament polarity, with NuMA?s friction being lower when moving towards minus-ends, EB1?s lower towards plus-ends, and PRC1 exhibiting no directional preference. Mathematical models predict, and experiments confirm, that MAPs with asymmetric friction can move directionally within active microtubule pairs they crosslink. Our findings reveal how non-motor MAPs can generate frictional resistance in dynamic cytoskeletal networks via micromechanical adaptations whose anisotropy may be optimized for MAP localization and function within cellular structures. äAsymmetric friction of non-motor MAPs can lead to their directional mo(epmc).pdf DeepDyve Pubget Overpricing