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Deprecated: Implicit conversion from float 294.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Anat+Rec+(Hoboken) 2014 ; 297 (4): 731-48 Nephropedia Template TP
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CONTRASTING HISTOPATHOLOGY AND CRYSTAL DEPOSITS IN KIDNEYS OF IDIOPATHIC STONE FORMERS WHO PRODUCE HYDROXY APATITE, BRUSHITE, OR CALCIUM OXALATE STONES #MMPMID24478243
Evan AP; Lingeman JE; Worcester EM; Sommer AJ; Phillips CL; Williams JC; Coe FL
Anat Rec (Hoboken) 2014[Apr]; 297 (4): 731-48 PMID24478243show ga
Our previous work has shown that stone formers who form calcium phosphate (CaP) stones that contain any brushite (BRSF) have a distinctive renal histopathology and surgical anatomy when compared to idiopathic calcium oxalate stone formers (ICSF). Here we report on another group of idiopathic CaP stone formers, those forming stone containing primarily hydroxyapatite, in order to clarify in what ways their pathology differs from BRSF and ICSF. Eleven hydroxyapatite stone formers (HASF) (2 males, 9 females) were studied using intra-operative digital photography and biopsy of papillary and cortical regions to measure tissue changes associated with stone formation. Our main finding is that HASF and BRSF differ significantly from each other and that both differ greatly from ICSF. Both BRSF and ICSF patients have significant levels of Randall?s plaque compared to HASF. Intra-tubular deposit number is greater in HASF than BRSF and non-existent in ICSF while deposit size is smaller in HASF than BRSF. Cortical pathology is distinctly greater in BRSF than HASF. Four attached stones were observed in HASF, three in 25 BRSF and 5?10 per ICSF patient. HASF and BRSF differ clinically in that both have higher average urine pH, supersaturation of CaP, and calcium excretion than ICSF. Our work suggests that HASF and BRSF are two distinct and separate diseases and both differ greatly from ICSF.