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10.1038/cdd.2014.8 http://scihub22266oqcxt.onion/10.1038/cdd.2014.8 C4013522!4013522!24510127     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2014 ; 21 (6): 854-63 Nephropedia Template TP {{tp|p=24510127|t=2014. Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation |pdf=|usr=}}{{24510127}} gab.com Text Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=24510127 #FOAvip TAZ, a transcriptional modulator, has a key role in cell proliferation, differentiation and stem cell self-renewal. TAZ activity is regulated by several signalling pathways, including Hippo, GPCR and Wnt signalling, but the regulatory mechanisms of TAZ activation are not yet clearly understood. In this report, we show that TAZ is regulated by canonical Wnt signalling during osteogenic differentiation. Wnt3a increases TAZ expression and an inhibitor of GSK3?, a downstream effector of Wnt signalling, induces TAZ. Wnt3a facilitates the dephosphorylation of TAZ, which stabilises TAZ and prevents it from binding 14-3-3 proteins, thus inducing the nuclear localisation of TAZ. Dephosphorylation of TAZ occurs via PP1A, and depletion of PP1A blocks Wnt3a-induced TAZ stabilisation. Wnt3a-induced TAZ activates osteoblastic differentiation and siRNA-induced TAZ depletion decreases Wnt3a-induced osteoblast differentiation. Taken together, these results show that TAZ mediates Wnt3a-stimulated osteogenic differentiation through PP1A, suggesting that the Wnt signal regulates the Hippo pathway. Twit Text FOAVip Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=24510127 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24510127 #FOAvip English Wikipedia <ref>{{Cite pmid|24510127}}</ref> Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation #MMPMID24510127 Byun MR; Hwang JH; Kim AR; Kim KM; Hwang ES; Yaffe MB; Hong JH Cell Death Differ 2014[Jun]; 21 (6): 854-63 PMID24510127show ga TAZ, a transcriptional modulator, has a key role in cell proliferation, differentiation and stem cell self-renewal. TAZ activity is regulated by several signalling pathways, including Hippo, GPCR and Wnt signalling, but the regulatory mechanisms of TAZ activation are not yet clearly understood. In this report, we show that TAZ is regulated by canonical Wnt signalling during osteogenic differentiation. Wnt3a increases TAZ expression and an inhibitor of GSK3?, a downstream effector of Wnt signalling, induces TAZ. Wnt3a facilitates the dephosphorylation of TAZ, which stabilises TAZ and prevents it from binding 14-3-3 proteins, thus inducing the nuclear localisation of TAZ. Dephosphorylation of TAZ occurs via PP1A, and depletion of PP1A blocks Wnt3a-induced TAZ stabilisation. Wnt3a-induced TAZ activates osteoblastic differentiation and siRNA-induced TAZ depletion decreases Wnt3a-induced osteoblast differentiation. Taken together, these results show that TAZ mediates Wnt3a-stimulated osteogenic differentiation through PP1A, suggesting that the Wnt signal regulates the Hippo pathway. äCanonical Wnt signalling activates TAZ through PP1A during osteogenic (epmc).pdf DeepDyve Pubget Overpricing