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10.1016/j.jcyt.2013.10.002

http://scihub22266oqcxt.onion/10.1016/j.jcyt.2013.10.002
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C4013208!4013208!24239105
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suck abstract from ncbi

pmid24239105      Cytotherapy 2014 ; 16 (6): 713-33
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  • Engineered T cells for cancer treatment #MMPMID24239105
  • Anurathapan U; Leen AM; Brenner MK; Vera JF
  • Cytotherapy 2014[Jun]; 16 (6): 713-33 PMID24239105show ga
  • Adoptively transferred T cells have the capacity to traffic to distant tumor sites, infiltrate even fibrotic tissue and kill antigen-expressing tumor cells. A variety of groups have investigated different genetic engineering strategies designed to enhance tumor specificity, increase T cell potency, improve proliferation, persistence, or migratory capacity, and increase safety. In this review we focus on recent developments in the T cell engineering arena, discuss the application of these engineered cell products clinically, and outline future prospects for this therapeutic modality.
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