Engineered T cells for cancer treatment #MMPMID24239105
Anurathapan U; Leen AM; Brenner MK; Vera JF
Cytotherapy 2014[Jun]; 16 (6): 713-33 PMID24239105show ga
Adoptively transferred T cells have the capacity to traffic to distant tumor sites, infiltrate even fibrotic tissue and kill antigen-expressing tumor cells. A variety of groups have investigated different genetic engineering strategies designed to enhance tumor specificity, increase T cell potency, improve proliferation, persistence, or migratory capacity, and increase safety. In this review we focus on recent developments in the T cell engineering arena, discuss the application of these engineered cell products clinically, and outline future prospects for this therapeutic modality.