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10.1007/s10549-014-2886-x http://scihub22266oqcxt.onion/10.1007/s10549-014-2886-x C4010120!4010120!24573543     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Breast+Cancer+Res+Treat 2014 ; 144 (2): 427-35 Nephropedia Template TP {{tp|p=24573543|t=2014. Digoxin use and risk of invasive breast cancer: Evidence from the Nurses? Health Study and meta-analysis |pdf=|usr=}}{{24573543}} gab.com Text Digoxin use and risk of invasive breast cancer: Evidence from the Nurses Health Study and meta-analysis JO: Breast Cancer Res Treat http://www.kidney.de/pget.php?&tw=1&pmid=24573543 #FOAvip Purpose: Despite preclinical evidence supporting anti-cancer effects of cardiac glycosides, epidemiologic studies consistently show elevated breast cancer risk in digoxin users. We studied this association in the Nurses? Health Study cohort to evaluate influences of screening mammography and lifestyle-related risk factors. Methods: We followed 90,202 postmenopausal women from 1994 until 2010. Self-reported breast cancers were confirmed by medical record review. We fit Cox regression models to estimate associations between time-varying digoxin use and breast cancer incidence, overall and by tumor ER status, accounting for mammography screening and established breast cancer risk factors. Results: There were 5,004 digoxin users over 1.05 million person-years of observation, among whom 144 breast cancer cases occurred. Digoxin users were more likely to undergo mammographic screening, to be former users of postmenopausal hormones, and to take other medications than never-users; the groups were similar on reproductive history and alcohol consumption. Current digoxin use of >4 years? duration was associated with a 45% increased rate of breast cancer compared with never use (HRadj=1.45, 95% CI: 1.13, 1.86). The association appeared stronger for ER-positive disease (HRadj=1.46, 95% CI: 1.10, 1.95) than for ER-negative disease (HRadj=1.12, 95% CI: 0.52, 2.37). Associations were robust to restriction on regular mammography use and to adjustment for established breast cancer risk factors, including lifestyle-related exposures. Conclusions: The positive association between digoxin use and breast cancer occurrence was not attenuated when lifestyle-related breast cancer risk factors and screening practices were accounted for. Digoxin, a common cardiac drug worldwide, may promote breast carcinogenesis. Twit Text FOAVip Digoxin use and risk of invasive breast cancer: Evidence from the Nurses Health Study and meta-analysis ????Breast Cancer Res Treat http://www.kidney.de/pget.php?&tw=1&pmid=24573543 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24573543 #FOAvip English Wikipedia <ref>{{Cite pmid|24573543}}</ref> Digoxin use and risk of invasive breast cancer: Evidence from the Nurses? Health Study and meta-analysis #MMPMID24573543 Ahern TP; Tamimi RM; Rosner BA; Hankinson SE Breast Cancer Res Treat 2014[Apr]; 144 (2): 427-35 PMID24573543show ga Purpose: Despite preclinical evidence supporting anti-cancer effects of cardiac glycosides, epidemiologic studies consistently show elevated breast cancer risk in digoxin users. We studied this association in the Nurses? Health Study cohort to evaluate influences of screening mammography and lifestyle-related risk factors. Methods: We followed 90,202 postmenopausal women from 1994 until 2010. Self-reported breast cancers were confirmed by medical record review. We fit Cox regression models to estimate associations between time-varying digoxin use and breast cancer incidence, overall and by tumor ER status, accounting for mammography screening and established breast cancer risk factors. Results: There were 5,004 digoxin users over 1.05 million person-years of observation, among whom 144 breast cancer cases occurred. Digoxin users were more likely to undergo mammographic screening, to be former users of postmenopausal hormones, and to take other medications than never-users; the groups were similar on reproductive history and alcohol consumption. Current digoxin use of >4 years? duration was associated with a 45% increased rate of breast cancer compared with never use (HRadj=1.45, 95% CI: 1.13, 1.86). The association appeared stronger for ER-positive disease (HRadj=1.46, 95% CI: 1.10, 1.95) than for ER-negative disease (HRadj=1.12, 95% CI: 0.52, 2.37). Associations were robust to restriction on regular mammography use and to adjustment for established breast cancer risk factors, including lifestyle-related exposures. Conclusions: The positive association between digoxin use and breast cancer occurrence was not attenuated when lifestyle-related breast cancer risk factors and screening practices were accounted for. Digoxin, a common cardiac drug worldwide, may promote breast carcinogenesis. äDigoxin use and risk of invasive breast cancer: Evidence from the Nurs(epmc).pdf DeepDyve Pubget Overpricing