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10.1021/ml900010b http://scihub22266oqcxt.onion/10.1021/ml900010b C4007969!4007969!24900169     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2010 ; 1 (1): 19-23 Nephropedia Template TP {{tp|p=24900169|t=2010. Synthesis and SAR of Benzisothiazole- and Indolizine-?-d-glucopyranoside Inhibitors of SGLT2 |pdf=|usr=}}{{24900169}} gab.com Text Synthesis and SAR of Benzisothiazole- and Indolizine- -d-glucopyranoside Inhibitors of SGLT2 JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900169 #FOAvip A series of benzisothiazole- and indolizine-?-d-glucopyranoside inhibitors of human SGLT2 are described. The synthesis of the C-linked heterocyclic glucosides took advantage of a palladium-catalyzed cross-coupling reaction between a glucal boronate and the corresponding bromo heterocycle. The compounds have been evaluated for their human SGLT2 inhibition potential using cell-based functional transporter assays, and their structure?activity relationships have been described. Benzisothiazole-C-glucoside 16d was found to be an inhibitor of SGLT2 with an IC50 of 10 nM. Twit Text FOAVip Synthesis and SAR of Benzisothiazole- and Indolizine- -d-glucopyranoside Inhibitors of SGLT2 ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900169 #FOAvip English Wikipedia <ref>{{Cite pmid|24900169}}</ref> Synthesis and SAR of Benzisothiazole- and Indolizine-?-d-glucopyranoside Inhibitors of SGLT2 #MMPMID24900169 Zhou H; Danger DP; Dock ST; Hawley L; Roller SG; Smith CD; Handlon AL ACS Med Chem Lett 2010[Apr]; 1 (1): 19-23 PMID24900169show ga A series of benzisothiazole- and indolizine-?-d-glucopyranoside inhibitors of human SGLT2 are described. The synthesis of the C-linked heterocyclic glucosides took advantage of a palladium-catalyzed cross-coupling reaction between a glucal boronate and the corresponding bromo heterocycle. The compounds have been evaluated for their human SGLT2 inhibition potential using cell-based functional transporter assays, and their structure?activity relationships have been described. Benzisothiazole-C-glucoside 16d was found to be an inhibitor of SGLT2 with an IC50 of 10 nM. äSynthesis and SAR of Benzisothiazole- and Indolizine-?-d-glucopyranosi(epmc).pdf DeepDyve Pubget Overpricing