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10.1021/ml100118k http://scihub22266oqcxt.onion/10.1021/ml100118k C4007961!4007961 !24900226     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24900226 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24900226 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2010 ; 1 (8 ): 416-21 Nephropedia Template TP {{tp|p=24900226 |t=2010. From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity |pdf=|usr=}}{{24900226 }} gab.com Text From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900226 #FOAvip Three simplified "non-natural" natural taxanes, related to taxuspine X, were synthetized and assayed as P-glycoprotein (P-gp) inhibitors. One of them (6) proved to be a very efficient P-gp inhibitor with an IC50 = 7.2 × 10(-6) M. In addition, to rationalize biological data, a pharmacophoric model was built through a ligand-based approach. This model represents the first example of a pharmacophore, which describes interactions of taxanes with P-gp. Twit Text FOAVip From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900226 #FOAvip English Wikipedia <ref>{{Cite pmid|24900226 }}</ref> From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity #MMPMID24900226 Castagnolo D ; Contemori L ; Maccari G ; Avramova SI ; Neri A ; Sgaragli G ; Botta M ACS Med Chem Lett 2010[Nov]; 1 (8 ): 416-21 PMID24900226 show ga Three simplified "non-natural" natural taxanes, related to taxuspine X, were synthetized and assayed as P-glycoprotein (P-gp) inhibitors. One of them (6) proved to be a very efficient P-gp inhibitor with an IC50 = 7.2 × 10(-6) M. In addition, to rationalize biological data, a pharmacophoric model was built through a ligand-based approach. This model represents the first example of a pharmacophore, which describes interactions of taxanes with P-gp. äFrom taxuspine x to structurally simplified taxanes with remarkable (epmc).pdf DeepDyve Pubget Overpricing