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10.1021/ml100143q http://scihub22266oqcxt.onion/10.1021/ml100143q C4007905!4007905!24900234     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2010 ; 1 (9): 478-82 Nephropedia Template TP {{tp|p=24900234|t=2010. A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis |pdf=|usr=}}{{24900234}} gab.com Text A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900234 #FOAvip AMP-activated protein kinase (AMPK) is a heterotrimeric kinase that regulates cellular energy metabolism by affecting energy-consuming pathways such as de novo lipid biosynthesis and glucose production as well as energy-producing pathways such as lipid oxidation and glucose uptake. Accordingly, compounds that activate AMPK represent potential drug candidates for the treatment of hyperlipidemia and type 2 diabetes. Screening of a proprietary library of AMP mimetics identified the phosphonic acid 2 that bears little structural resemblance to AMP but is capable of activating AMPK with high potency (EC50 = 6 nM vs AMP EC50 = 6 ?M) and specificity. Phosphonate prodrugs of 2 inhibited de novo lipogenesis in cellular and animal models of hyperlipidemia. Twit Text FOAVip A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900234 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900234 #FOAvip English Wikipedia <ref>{{Cite pmid|24900234}}</ref> A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis #MMPMID24900234 Gómez-Galeno JE; Dang Q; Nguyen TH; Boyer SH; Grote MP; Sun Z; Chen M; Craigo WA; van Poelje PD; MacKenna DA; Cable EE; Rolzin PA; Finn PD; Chi B; Linemeyer DL; Hecker SJ; Erion MD ACS Med Chem Lett 2010[Dec]; 1 (9): 478-82 PMID24900234show ga AMP-activated protein kinase (AMPK) is a heterotrimeric kinase that regulates cellular energy metabolism by affecting energy-consuming pathways such as de novo lipid biosynthesis and glucose production as well as energy-producing pathways such as lipid oxidation and glucose uptake. Accordingly, compounds that activate AMPK represent potential drug candidates for the treatment of hyperlipidemia and type 2 diabetes. Screening of a proprietary library of AMP mimetics identified the phosphonic acid 2 that bears little structural resemblance to AMP but is capable of activating AMPK with high potency (EC50 = 6 nM vs AMP EC50 = 6 ?M) and specificity. Phosphonate prodrugs of 2 inhibited de novo lipogenesis in cellular and animal models of hyperlipidemia. äA Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesi(epmc).pdf DeepDyve Pubget Overpricing