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10.1021/ml900018m http://scihub22266oqcxt.onion/10.1021/ml900018m C4007900!4007900 !24900171     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24900171 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2010 ; 1 (1 ): 30-4 Nephropedia Template TP {{tp|p=24900171 |t=2010. Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295 |pdf=|usr=}}{{24900171 }} gab.com Text Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295 JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900171 #FOAvip Inhibition of mitotic kinesins represents a novel approach for the discovery of a new generation of anti-mitotic cancer chemotherapeutics. We report here the discovery of the first potent and selective inhibitor of centromere-associated protein E (CENP-E) 3-chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide (GSK923295; 1), starting from a high-throughput screening hit, 3-chloro-4-isopropoxybenzoic acid 2. Compound 1 has demonstrated broad antitumor activity in vivo and is currently in human clinical trials. Twit Text FOAVip Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295 ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900171 #FOAvip English Wikipedia <ref>{{Cite pmid|24900171 }}</ref> Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295 #MMPMID24900171 Qian X ; McDonald A ; Zhou HJ ; Adams ND ; Parrish CA ; Duffy KJ ; Fitch DM ; Tedesco R ; Ashcraft LW ; Yao B ; Jiang H ; Huang JK ; Marin MV ; Aroyan CE ; Wang J ; Ahmed S ; Burgess JL ; Chaudhari AM ; Donatelli CA ; Darcy MG ; Ridgers LH ; Newlander KA ; Schmidt SJ ; Chai D ; Colón M ; Zimmerman MN ; Lad L ; Sakowicz R ; Schauer S ; Belmont L ; Baliga R ; Pierce DW ; Finer JT ; Wang Z ; Morgan BP ; Morgans DJ Jr ; Auger KR ; Sung CM ; Carson JD ; Luo L ; Hugger ED ; Copeland RA ; Sutton D ; Elliott JD ; Jackson JR ; Wood KW ; Dhanak D ; Bergnes G ; Knight SD ACS Med Chem Lett 2010[Apr]; 1 (1 ): 30-4 PMID24900171 show ga Inhibition of mitotic kinesins represents a novel approach for the discovery of a new generation of anti-mitotic cancer chemotherapeutics. We report here the discovery of the first potent and selective inhibitor of centromere-associated protein E (CENP-E) 3-chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide (GSK923295; 1), starting from a high-throughput screening hit, 3-chloro-4-isopropoxybenzoic acid 2. Compound 1 has demonstrated broad antitumor activity in vivo and is currently in human clinical trials. äDiscovery of the First Potent and Selective Inhibitor of Centromere-As(epmc).pdf DeepDyve Pubget Overpricing