Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1021/ml100044h http://scihub22266oqcxt.onion/10.1021/ml100044h C4007842!4007842!24900194     free     free     free       ACS+Med+Chem+Lett 2010 ; 1 (5): 199-203 Nephropedia Template TP {{tp|p=24900194|t=2010. Allosteric IGF-1R Inhibitors |pdf=|usr=}}{{24900194}} gab.com Text Allosteric IGF-1R Inhibitors JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900194 #FOAvip Targeting allosteric protein sites is a promising approach to interfere selectively with cellular signaling cascades. We have discovered a novel class of allosteric insulin-like growth factor-I receptor (IGF-1R) inhibitors. 3-Cyano-1H-indole-7-carboxylic acid {1-[4-(5-cyano-1H-indol-3-yl)butyl]piperidin-4-yl}amide (10) was found with nanomolar biochemical, micromolar, cellular IGF-1R activity and no relevant interference with cellular insulin receptor signaling up to 30 ?M. The allosteric binding site was characterized by X-ray crystallographic studies, and the structural information was used to explain the unique mode of action of this new class of inhibitors. Twit Text FOAVip Allosteric IGF-1R Inhibitors ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900194 #FOAvip English Wikipedia <ref>{{Cite pmid|24900194}}</ref> Allosteric IGF-1R Inhibitors #MMPMID24900194 Heinrich T; Grädler U; Böttcher H; Blaukat A; Shutes A ACS Med Chem Lett 2010[Aug]; 1 (5): 199-203 PMID24900194show ga Targeting allosteric protein sites is a promising approach to interfere selectively with cellular signaling cascades. We have discovered a novel class of allosteric insulin-like growth factor-I receptor (IGF-1R) inhibitors. 3-Cyano-1H-indole-7-carboxylic acid {1-[4-(5-cyano-1H-indol-3-yl)butyl]piperidin-4-yl}amide (10) was found with nanomolar biochemical, micromolar, cellular IGF-1R activity and no relevant interference with cellular insulin receptor signaling up to 30 ?M. The allosteric binding site was characterized by X-ray crystallographic studies, and the structural information was used to explain the unique mode of action of this new class of inhibitors. äAllosteric IGF-1R Inhibitors (epmc).pdf DeepDyve Pubget Overpricing