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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 ACS+Med+Chem+Lett
2010 ; 1
(4
): 175-9
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gab.com Text
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Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on
Intraocular Pressure in Rats
#MMPMID24900192
Yin Y
; Cameron MD
; Lin L
; Khan S
; Schröter T
; Grant W
; Pocas J
; Chen YT
; Schürer S
; Pachori A
; LoGrasso P
; Feng Y
ACS Med Chem Lett
2010[Jul]; 1
(4
): 175-9
PMID24900192
show ga
A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated.
The discovered compounds had excellent enzyme and cellular potency, high kinase
selectivity, high aqueous solubility, good porcine corneal penetration, and
appropriate DMPK profiles for topical applications as antiglaucoma therapeutics.