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10.1021/ml1000382

http://scihub22266oqcxt.onion/10.1021/ml1000382
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C4007833!4007833 !24900192
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suck abstract from ncbi


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pmid24900192
      ACS+Med+Chem+Lett 2010 ; 1 (4 ): 175-9
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  • Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats #MMPMID24900192
  • Yin Y ; Cameron MD ; Lin L ; Khan S ; Schröter T ; Grant W ; Pocas J ; Chen YT ; Schürer S ; Pachori A ; LoGrasso P ; Feng Y
  • ACS Med Chem Lett 2010[Jul]; 1 (4 ): 175-9 PMID24900192 show ga
  • A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate DMPK profiles for topical applications as antiglaucoma therapeutics.
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