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10.1016/j.drudis.2013.10.018

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C4004703!4004703!24184433
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suck abstract from ncbi


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pmid24184433      Drug+Discov+Today 2014 ; 19 (4): 469-73
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  • DREADDs: novel tools for drug discovery and development #MMPMID24184433
  • Lee HM; Giguere PM; Roth BL
  • Drug Discov Today 2014[Apr]; 19 (4): 469-73 PMID24184433show ga
  • Since the invention of the first designer receptors exclusively activated by designer drugs (DREADDs), these engineered G protein-coupled receptors (GPCRs) have been widely applied in investigations of biological processes and behaviors. DREADD technology has emerged as a powerful tool with great potential for drug discovery and development. DREADDs can facilitate the identification of druggable targets and enable researchers to explore the activities of novel drugs against both known and orphan GPCRs. Here, we discuss how DREADDs can be used as novel tools for drug discovery and development.
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