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10.1016/j.cell.2014.02.030 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.02.030 C4004670!4004670!24726434     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 157 (3): 580-94 Nephropedia Template TP {{tp|p=24726434|t=2014. Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells |pdf=|usr=}}{{24726434}} gab.com Text Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24726434 #FOAvip Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies reminiscent of normal development but superimposed on underlying genetic aberrations. In glioblastoma (GBM), a subset of stem-like tumor-propagating cells (TPCs) appears to drive tumor progression and underlie therapeutic resistance, yet remain poorly understood. Here, we identify a core set of neurodevelopmental TFs (POU3F2, SOX2, SALL2, OLIG2) essential for GBM propagation. These TFs coordinately bind and activate TPC-specific regulatory elements, and are sufficient to fully reprogram differentiated GBM cells to ?induced? TPCs, recapitulating the epigenetic landscape and phenotype of native TPCs. We reconstruct a network model that highlights critical interactions and identifies novel therapeutic targets for eliminating TPCs. Our study establishes the epigenetic basis of a developmental hierarchy in GBM, provides detailed insight into underlying gene regulatory programs, and suggests attendant therapeutic strategies. Twit Text FOAVip Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24726434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24726434 #FOAvip English Wikipedia <ref>{{Cite pmid|24726434}}</ref> Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells #MMPMID24726434 Suvā ML; Rheinbay E; Gillespie SM; Patel AP; Wakimoto H; Rabkin SD; Riggi N; Chi AS; Cahill DP; Nahed BV; Curry WT; Martuza RL; Rivera MN; Rossetti N; Kasif S; Beik S; Kadri S; Tirosh I; Wortman I; Shalek A; Rozenblatt-Rosen O; Regev A; Louis DN; Bernstein BE Cell 2014[Apr]; 157 (3): 580-94 PMID24726434show ga Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies reminiscent of normal development but superimposed on underlying genetic aberrations. In glioblastoma (GBM), a subset of stem-like tumor-propagating cells (TPCs) appears to drive tumor progression and underlie therapeutic resistance, yet remain poorly understood. Here, we identify a core set of neurodevelopmental TFs (POU3F2, SOX2, SALL2, OLIG2) essential for GBM propagation. These TFs coordinately bind and activate TPC-specific regulatory elements, and are sufficient to fully reprogram differentiated GBM cells to ?induced? TPCs, recapitulating the epigenetic landscape and phenotype of native TPCs. We reconstruct a network model that highlights critical interactions and identifies novel therapeutic targets for eliminating TPCs. Our study establishes the epigenetic basis of a developmental hierarchy in GBM, provides detailed insight into underlying gene regulatory programs, and suggests attendant therapeutic strategies. äReconstructing and reprogramming the tumor propagating potential of gl(epmc).pdf DeepDyve Pubget Overpricing