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10.1074/jbc.M114.553859

http://scihub22266oqcxt.onion/10.1074/jbc.M114.553859
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C4002120!4002120!24616106
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suck abstract from ncbi


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pmid24616106      J+Biol+Chem 2014 ; 289 (17): 12168-76
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  • O-GlcNAc Transferase Is Critical for Transducin-like Enhancer of Split (TLE)-mediated Repression of Canonical Wnt Signaling* #MMPMID24616106
  • Wu J; Bowe DB; Sadlonova A; Whisenhunt TR; Hu Y; Rustgi AK; Nie Y; Paterson AJ; Yang X
  • J Biol Chem 2014[Apr]; 289 (17): 12168-76 PMID24616106show ga
  • Background: The molecular mechanisms by which Groucho/TLEs repress canonical Wnt signaling are incompletely understood.Results: OGT interacts with TLEs and facilitates TLE-mediated transcriptional repression. Removal of O-GlcNAc is essential for gene activation from Wnt-responsive promoters.Conclusion: OGT plays a vital role in TLE-mediated repression of Wnt signaling.Significance:O-GlcNAc modification has a profound influence on diverse signaling pathways.
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