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10.1074/jbc.M114.553859 http://scihub22266oqcxt.onion/10.1074/jbc.M114.553859 C4002120!4002120 !24616106     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24616106 &cmd=llinks): Failed to open stream: HTTP request failed! 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O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonical Wnt signaling |pdf=|usr=}}{{24616106 }} gab.com Text O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonical Wnt signaling JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24616106 #FOAvip The Drosophila Groucho protein and its mammalian orthologues the transducin-like enhancers of split (TLEs) are critical transcriptional corepressors that repress Wnt and other signaling pathways. Although it is known that Groucho/TLEs are recruited to target genes by pathway-specific transcription factors, molecular events after the corepressor recruitment are largely unclear. We report that association of TLEs with O-GlcNAc transferase, an enzyme that catalyzes posttranslational modification of proteins by O-linked N-acetylglucosamine, is essential for TLE-mediated transcriptional repression. Removal of O-GlcNAc from Wnt-responsive gene promoters is critical for gene activation from Wnt-responsive promoters. Thus, these studies identify a molecular mechanism by which Groucho/TLEs repress gene transcription and provide a model whereby O-GlcNAc may control distinct intracellular signaling pathways. Twit Text FOAVip O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonical Wnt signaling ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24616106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24616106 #FOAvip English Wikipedia <ref>{{Cite pmid|24616106 }}</ref> O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonical Wnt signaling #MMPMID24616106 Wu J ; Bowe DB ; Sadlonova A ; Whisenhunt TR ; Hu Y ; Rustgi AK ; Nie Y ; Paterson AJ ; Yang X J Biol Chem 2014[Apr]; 289 (17 ): 12168-12176 PMID24616106 show ga The Drosophila Groucho protein and its mammalian orthologues the transducin-like enhancers of split (TLEs) are critical transcriptional corepressors that repress Wnt and other signaling pathways. Although it is known that Groucho/TLEs are recruited to target genes by pathway-specific transcription factors, molecular events after the corepressor recruitment are largely unclear. We report that association of TLEs with O-GlcNAc transferase, an enzyme that catalyzes posttranslational modification of proteins by O-linked N-acetylglucosamine, is essential for TLE-mediated transcriptional repression. Removal of O-GlcNAc from Wnt-responsive gene promoters is critical for gene activation from Wnt-responsive promoters. Thus, these studies identify a molecular mechanism by which Groucho/TLEs repress gene transcription and provide a model whereby O-GlcNAc may control distinct intracellular signaling pathways. |*Signal Transduction [MESH] |*Wnt Signaling Pathway [MESH] |Animals [MESH] |Base Sequence [MESH] |Chromatin Immunoprecipitation [MESH] |DNA Primers [MESH] |Drosophila [MESH] |Humans [MESH] |N-Acetylglucosaminyltransferases/*metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH]O-GlcNAc transferase is critical for transducin-like enhancer of split(epmc).pdf DeepDyve Pubget Overpricing