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10.1074/jbc.M113.537449

http://scihub22266oqcxt.onion/10.1074/jbc.M113.537449
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C4002112!4002112!24627484
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suck abstract from ncbi


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pmid24627484      J+Biol+Chem 2014 ; 289 (17): 12063-76
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  • The Lantibiotic NAI-107 Binds to Bactoprenol-bound Cell Wall Precursors and Impairs Membrane Functions* #MMPMID24627484
  • Münch D; Müller A; Schneider T; Kohl B; Wenzel M; Bandow JE; Maffioli S; Sosio M; Donadio S; Wimmer R; Sahl HG
  • J Biol Chem 2014[Apr]; 289 (17): 12063-76 PMID24627484show ga
  • Background: NAI-107 is a potent lantibiotic with an unknown mode of action.Results: NAI-107 targets bactoprenol-bound cell envelope precursors, e.g. lipid II, and in addition affects the bacterial membrane.Conclusion: Cell wall biosynthesis is blocked by sequestration of lipid II and functional disorganization of the cell wall machinery.Significance: The dual mechanism of action may explain the potency of NAI-107 and related lantibiotics.
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