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10.1074/jbc.M113.533299 http://scihub22266oqcxt.onion/10.1074/jbc.M113.533299 C4002095!4002095 !24627489     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24627489 &cmd=llinks): Failed to open stream: HTTP request failed! 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Transient contraction of mitochondria induces depolarization through the inner membrane dynamin OPA1 protein |pdf=|usr=}}{{24627489 }} gab.com Text Transient contraction of mitochondria induces depolarization through the inner membrane dynamin OPA1 protein JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24627489 #FOAvip Dynamin-related membrane remodeling proteins regulate mitochondrial morphology by mediating fission and fusion. Although mitochondrial morphology is considered an important factor in maintaining mitochondrial function, a direct mechanistic link between mitochondrial morphology and function has not been defined. We report here a previously unrecognized cellular process of transient contraction of the mitochondrial matrix. Importantly, we found that this transient morphological contraction of mitochondria is accompanied by a reversible loss or decrease of inner membrane potential. Fission deficiency greatly amplified this phenomenon, which functionally exhibited an increase of inner membrane proton leak. We found that electron transport activity is necessary for the morphological contraction of mitochondria. Furthermore, we discovered that silencing the inner membrane-associated dynamin optic atrophy 1 (OPA1) in fission deficiency prevented mitochondrial depolarization and decreased proton leak without blocking mitochondrial contraction, indicating that OPA1 is a factor in coupling matrix contraction to mitochondrial depolarization. Our findings show that transient matrix contraction is a novel cellular mechanism regulating mitochondrial activity through the function of the inner membrane dynamin OPA1. Twit Text FOAVip Transient contraction of mitochondria induces depolarization through the inner membrane dynamin OPA1 protein ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24627489 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24627489 #FOAvip English Wikipedia <ref>{{Cite pmid|24627489 }}</ref> Transient contraction of mitochondria induces depolarization through the inner membrane dynamin OPA1 protein #MMPMID24627489 Lee H ; Yoon Y J Biol Chem 2014[Apr]; 289 (17 ): 11862-11872 PMID24627489 show ga Dynamin-related membrane remodeling proteins regulate mitochondrial morphology by mediating fission and fusion. Although mitochondrial morphology is considered an important factor in maintaining mitochondrial function, a direct mechanistic link between mitochondrial morphology and function has not been defined. We report here a previously unrecognized cellular process of transient contraction of the mitochondrial matrix. Importantly, we found that this transient morphological contraction of mitochondria is accompanied by a reversible loss or decrease of inner membrane potential. Fission deficiency greatly amplified this phenomenon, which functionally exhibited an increase of inner membrane proton leak. We found that electron transport activity is necessary for the morphological contraction of mitochondria. Furthermore, we discovered that silencing the inner membrane-associated dynamin optic atrophy 1 (OPA1) in fission deficiency prevented mitochondrial depolarization and decreased proton leak without blocking mitochondrial contraction, indicating that OPA1 is a factor in coupling matrix contraction to mitochondrial depolarization. Our findings show that transient matrix contraction is a novel cellular mechanism regulating mitochondrial activity through the function of the inner membrane dynamin OPA1. |Animals [MESH] |Cells, Cultured [MESH] |Electron Transport [MESH] |GTP Phosphohydrolases [MESH] |Intracellular Membranes/*metabolism [MESH] |Membrane Potential, Mitochondrial [MESH] |Mice [MESH] |Mice, Knockout [MESH]Transient contraction of mitochondria induces depolarization through t(epmc).pdf DeepDyve Pubget Overpricing