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10.1242/bio.20147328 http://scihub22266oqcxt.onion/10.1242/bio.20147328 C4001238!4001238!24526714     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biol+Open 2014 ; 3 (3): 185-94 Nephropedia Template TP {{tp|p=24526714|t=2014. Mutations of Cx43 that affect B cell spreading in response to BCR signaling |pdf=|usr=}}{{24526714}} gab.com Text Mutations of Cx43 that affect B cell spreading in response to BCR signaling JO: Biol Open http://www.kidney.de/pget.php?&tw=1&pmid=24526714 #FOAvip The gap junction (GJ) protein connexin 43 (Cx43) is both necessary and sufficient for B cell receptor (BCR)-mediated cell spreading. To address how Cx43 mediates this effect, we blocked its function genetically, by expressing mutants of Cx43, and pharmacologically, by using chemical inhibitors. While various point mutations of Cx43 inhibited B cell spreading, treatment with channel blocking drugs did not, suggesting that this response was independent of channel function. The critical region of Cx43 appears to be the cytoplasmic carboxyl-terminal (CT) domain, which has previously been shown to be important for B cell spreading. Consistent with this, mutations of either tyrosine 247 or 265 found in the CT were sufficient to inhibit spreading. Thus Cx43 may influence B cell spreading by mechanisms requiring protein binding to, or modification of, these sites in the CT tail. Twit Text FOAVip Mutations of Cx43 that affect B cell spreading in response to BCR signaling ????Biol Open http://www.kidney.de/pget.php?&tw=1&pmid=24526714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24526714 #FOAvip English Wikipedia <ref>{{Cite pmid|24526714}}</ref> Mutations of Cx43 that affect B cell spreading in response to BCR signaling #MMPMID24526714 Falk L; Dang-Lawson M; Vega JL; Pournia F; Choi K; Jang C; Naus CC; Matsuuchi L Biol Open 2014[Mar]; 3 (3): 185-94 PMID24526714show ga The gap junction (GJ) protein connexin 43 (Cx43) is both necessary and sufficient for B cell receptor (BCR)-mediated cell spreading. To address how Cx43 mediates this effect, we blocked its function genetically, by expressing mutants of Cx43, and pharmacologically, by using chemical inhibitors. While various point mutations of Cx43 inhibited B cell spreading, treatment with channel blocking drugs did not, suggesting that this response was independent of channel function. The critical region of Cx43 appears to be the cytoplasmic carboxyl-terminal (CT) domain, which has previously been shown to be important for B cell spreading. Consistent with this, mutations of either tyrosine 247 or 265 found in the CT were sufficient to inhibit spreading. Thus Cx43 may influence B cell spreading by mechanisms requiring protein binding to, or modification of, these sites in the CT tail. äMutations of Cx43 that affect B cell spreading in response to BCR sign(epmc).pdf DeepDyve Pubget Overpricing