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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cytokine+Growth+Factor+Rev 2014 ; 25 (2): 215-25 Nephropedia Template TP
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The TWEAK-Fn14 Pathway: A Potent Regulator of Skeletal Muscle Biology in Health and Disease #MMPMID24444596
Tajrishi MM; Zheng TS; Burkly LC; Kumar A
Cytokine Growth Factor Rev 2014[Apr]; 25 (2): 215-25 PMID24444596show ga
TNF-like weak inducer of apoptosis (TWEAK), a TNF superfamily ligand, and its bona fide receptor, the TNF receptor superfamily member fibroblast growth factor-inducible protein 14 (Fn14), represents a pivotal axis for shaping both physiological and pathological tissue responses to acute or chronic injury and disease. In recent years significant advances have been made in delineating the prominent role of this axis in regulating skeletal muscle mass and metabolism. Also emerging from the broad study of tissue injury in skeletal muscle and other organs is the role of the TWEAK-Fn14 pathway in promoting fibrosis. This review article highlights recent advancements towards understanding how the TWEAK-Fn14 pathway regulates the response to various skeletal muscle insults and more broadly, engages multiple mechanisms to drive tissue fibrosis.