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10.1016/j.cytogfr.2014.01.001

http://scihub22266oqcxt.onion/10.1016/j.cytogfr.2014.01.001
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C3999179!3999179!24507939
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suck abstract from ncbi


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pmid24507939      Cytokine+Growth+Factor+Rev 2014 ; 25 (2): 107-13
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  • New roles for the BLyS/BAFF family in antigen-experienced B cell niches #MMPMID24507939
  • Goenka R; Scholz JL; Sindhava VJ; Cancro MP
  • Cytokine Growth Factor Rev 2014[Apr]; 25 (2): 107-13 PMID24507939show ga
  • BLyS family members govern selection and survival of cells in the preimmune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity maturation in germinal centers, which lie at the intersection of the pre-immune and antigen-experienced B cell compartments. We propose a model whereby tolerogenic selection at the transitional stage and affinity maturation in the germinal center employ the same BLyS driven mechanism.
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