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10.1097/01.TP.0000442504.23885.f7 http://scihub22266oqcxt.onion/10.1097/01.TP.0000442504.23885.f7 C3997508!3997508!24642686     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Transplantation 2014 ; 97 (7): 740-7 Nephropedia Template TP {{tp|p=24642686|t=2014. Co-transplantation with Myeloid-Derived Suppressor Cells Protects Cell Transplants: A Crucial Role of Inducible Nitric Oxide Synthase |pdf=|usr=}}{{24642686}} gab.com Text Co-transplantation with Myeloid-Derived Suppressor Cells Protects Cell Transplants: A Crucial Role of Inducible Nitric Oxide Synthase JO: Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=24642686 #FOAvip Background: Islet transplantation is an alternative to pancreas transplantation to cure type 1 diabetes, but both require chronic immunosuppression, which is often accompanied by deleterious side effects. The purpose of this study was to explore prolongation of islet allograft survival by co-transplantation with myeloid-derived suppressor cells (MDSCs) without requirement of immunosuppression, and determine the role of inducible nitric oxide synthase (iNOS) produced by MDSCs in immune regulation. Methods: Bone marrow cells were isolated from wild type (WT) or iNOS?/? mice and cultured in the presence of GM-CSF and hepatic stellate cells (HSCs), resulting in the generation of MDSCs. WT or iNOS?/? MDSCs were co-transplanted with islet allografts under the renal capsule of diabetic recipient mice. Results: Addition of HSCs into DC culture promoted generation of MDSCs (instead of DCs). MDSCs had elevated expression of iNOS upon exposure to IFN-? and inhibited T cell responses in an MLR culture. Co-transplantation with WT MDSCs markedly prolonged survival of islet allografts, which was associated with reduced infiltration of CD8+ T cells due to inhibited proliferative response. These effects were significantly attenuated when MDSCs were deficient in iNOS. Furthermore, iNOS?/? MDSCs largely lost their ability to protect islet allografts. Conclusions: Co-transplantation with HSC-induced MDSCs significantly extends islet allograft survival through iNOS-mediated T cell inhibition. The results demonstrate the potential use of in vitro generated MDSCs as a novel adjunctive immunotherapy for islet transplantation. Twit Text FOAVip Co-transplantation with Myeloid-Derived Suppressor Cells Protects Cell Transplants: A Crucial Role of Inducible Nitric Oxide Synthase ????Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=24642686 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24642686 #FOAvip English Wikipedia <ref>{{Cite pmid|24642686}}</ref> Co-transplantation with Myeloid-Derived Suppressor Cells Protects Cell Transplants: A Crucial Role of Inducible Nitric Oxide Synthase #MMPMID24642686 Arakawa Y; Qin J; Chou HS; Bhatt S; Wang L; Stuehr D; Ghosh A; Fung JJ; Lu L; Qian S Transplantation 2014[Apr]; 97 (7): 740-7 PMID24642686show ga Background: Islet transplantation is an alternative to pancreas transplantation to cure type 1 diabetes, but both require chronic immunosuppression, which is often accompanied by deleterious side effects. The purpose of this study was to explore prolongation of islet allograft survival by co-transplantation with myeloid-derived suppressor cells (MDSCs) without requirement of immunosuppression, and determine the role of inducible nitric oxide synthase (iNOS) produced by MDSCs in immune regulation. Methods: Bone marrow cells were isolated from wild type (WT) or iNOS?/? mice and cultured in the presence of GM-CSF and hepatic stellate cells (HSCs), resulting in the generation of MDSCs. WT or iNOS?/? MDSCs were co-transplanted with islet allografts under the renal capsule of diabetic recipient mice. Results: Addition of HSCs into DC culture promoted generation of MDSCs (instead of DCs). MDSCs had elevated expression of iNOS upon exposure to IFN-? and inhibited T cell responses in an MLR culture. Co-transplantation with WT MDSCs markedly prolonged survival of islet allografts, which was associated with reduced infiltration of CD8+ T cells due to inhibited proliferative response. These effects were significantly attenuated when MDSCs were deficient in iNOS. Furthermore, iNOS?/? MDSCs largely lost their ability to protect islet allografts. Conclusions: Co-transplantation with HSC-induced MDSCs significantly extends islet allograft survival through iNOS-mediated T cell inhibition. The results demonstrate the potential use of in vitro generated MDSCs as a novel adjunctive immunotherapy for islet transplantation. äCo-transplantation with Myeloid-Derived Suppressor Cells Protects Cell(epmc).pdf DeepDyve Pubget Overpricing