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2014 ; 4
(3
): 20130073
Nephropedia Template TP
gab.com Text
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English Wikipedia
Modelling chromosome dynamics in mitosis: a historical perspective on models of
metaphase and anaphase in eukaryotic cells
#MMPMID24904736
Civelekoglu-Scholey G
; Cimini D
Interface Focus
2014[Jun]; 4
(3
): 20130073
PMID24904736
show ga
Mitosis is the process by which the genome is segregated to form two identical
daughter cells during cell division. The process of cell division is essential to
the maintenance of every form of life. However, a detailed quantitative
understanding of mitosis has been difficult owing to the complexity of the
process. Indeed, it has been long recognized that, because of the complexity of
the molecules involved, their dynamics and their properties, the mitotic events
that mediate the segregation of the genome into daughter nuclei cannot be fully
understood without the contribution of mathematical/quantitative modelling. Here,
we provide an overview of mitosis and describe the dynamic and mechanical
properties of the mitotic apparatus. We then discuss several quantitative models
that emerged in the past decades and made an impact on our understanding of
specific aspects of mitosis, including the motility of the chromosomes within the
mitotic spindle during metaphase and anaphase, the maintenance of spindle length
during metaphase and the switch to spindle elongation that occurs during
anaphase.