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10.1101/cshperspect.a016931 http://scihub22266oqcxt.onion/10.1101/cshperspect.a016931 C3996470!3996470!24789821     free     free     free       Cold+Spring+Harb+Perspect+Biol 2014 ; 6 (5): ä Nephropedia Template TP {{tp|p=24789821|t=2014. Role of Endosomes and Lysosomes in Human Disease |pdf=|usr=}}{{24789821}} gab.com Text Role of Endosomes and Lysosomes in Human Disease JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=24789821 #FOAvip In addition to their roles in normal cell physiology, endocytic processes play a key role in many diseases. In this review, three diseases are discussed as examples of the role of endocytic processes in disease. The uptake of cholesterol via LDL is central to our understanding of atherosclerosis, and the study of this disease led to many of the key breakthroughs in understanding receptor-mediated endocytosis. Alzheimer?s disease is a growing burden as the population ages. Endosomes and lysosomes play important but only partially understood roles in both the formation and the degradation of the amyloid fibrils that are associated with Alzheimer?s disease. Inherited lysosomal storage diseases are individually rare, but collectively they affect many individuals. Recent advances are leading to improved enzyme replacement therapy and are also leading to small-molecule drugs to treat some of these diseases. Twit Text FOAVip Role of Endosomes and Lysosomes in Human Disease ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=24789821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24789821 #FOAvip English Wikipedia <ref>{{Cite pmid|24789821}}</ref> Role of Endosomes and Lysosomes in Human Disease #MMPMID24789821 Maxfield FR Cold Spring Harb Perspect Biol 2014[May]; 6 (5): ä PMID24789821show ga In addition to their roles in normal cell physiology, endocytic processes play a key role in many diseases. In this review, three diseases are discussed as examples of the role of endocytic processes in disease. The uptake of cholesterol via LDL is central to our understanding of atherosclerosis, and the study of this disease led to many of the key breakthroughs in understanding receptor-mediated endocytosis. Alzheimer?s disease is a growing burden as the population ages. Endosomes and lysosomes play important but only partially understood roles in both the formation and the degradation of the amyloid fibrils that are associated with Alzheimer?s disease. Inherited lysosomal storage diseases are individually rare, but collectively they affect many individuals. Recent advances are leading to improved enzyme replacement therapy and are also leading to small-molecule drugs to treat some of these diseases. äRole of Endosomes and Lysosomes in Human Disease (epmc).pdf DeepDyve Pubget Overpricing