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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cold+Spring+Harb+Perspect+Biol 2014 ; 6 (5): ä Nephropedia Template TP
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Molecular Structure, Function, and Dynamics of Clathrin-Mediated Membrane Traffic #MMPMID24789820
Kirchhausen T; Owen D; Harrison SC
Cold Spring Harb Perspect Biol 2014[May]; 6 (5): ä PMID24789820show ga
Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. This review describes the structures of clathrin, major cargo adaptors, and other proteins that participate in forming a clathrin-coated pit, loading its contents, pinching off the membrane as a lattice-enclosed vesicle, and recycling the components. It integrates as much of the structural information as possible at the time of writing into a sketch of the principal steps in coated-pit and coated-vesicle formation.