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10.1101/cshperspect.a014225

http://scihub22266oqcxt.onion/10.1101/cshperspect.a014225
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C3996374!3996374!24789872
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suck abstract from ncbi

pmid24789872      Cold+Spring+Harb+Perspect+Med 2014 ; 4 (5): ä
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  • MYC and Mitochondrial Biogenesis #MMPMID24789872
  • Morrish F; Hockenbery D
  • Cold Spring Harb Perspect Med 2014[May]; 4 (5): ä PMID24789872show ga
  • Mitochondria, the powerhouses of the cell, face two imperatives concerning biogenesis. The first is the requirement for dividing cells to replicate their mitochondrial content by growth of existing mitochondria. The second is the dynamic regulation of mitochondrial content in response to organismal and cellular cues (e.g., exercise, caloric restriction, energy status, temperature). MYC provides the clearest example of a programmed expansion of mitochondrial content linked to the cell cycle. As an oncogene, MYC also presents intriguing questions about the role of its mitochondrial targets in cancer-related phenotypes, such as the Warburg effect and MYC-dependent apoptosis.
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