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10.1007/s13311-013-0251-0 http://scihub22266oqcxt.onion/10.1007/s13311-013-0251-0 C3996119!3996119!24481729     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurotherapeutics 2014 ; 11 (2): 251-68 Nephropedia Template TP {{tp|p=24481729|t=2014. Epilepsy Related to Developmental Tumors and Malformations of Cortical Development |pdf=|usr=}}{{24481729}} gab.com Text Epilepsy Related to Developmental Tumors and Malformations of Cortical Development JO: Neurotherapeutics http://www.kidney.de/pget.php?&tw=1&pmid=24481729 #FOAvip Structural abnormalities of the brain are increasingly recognized in patients with neurodevelopmental delay and intractable focal epilepsies. The access to clinically well-characterized neurosurgical material has provided a unique opportunity to better define the neuropathological, neurochemical, and molecular features of epilepsy-associated focal developmental lesions. These studies help to further understand the epileptogenic mechanisms of these lesions. Neuropathological evaluation of surgical specimens from patients with epilepsy-associated developmental lesions reveals two major pathologies: focal cortical dysplasia and low-grade developmental tumors (glioneuronal tumors). In the last few years there have been major advances in the recognition of a wide spectrum of developmental lesions associated with a intractable epilepsy, including cortical tubers in patients with tuberous sclerosis complex and hemimegalencephaly. As an increasing number of entities are identified, the development of a unified and comprehensive classification represents a great challenge and requires continuous updates. The present article reviews current knowledge of molecular pathogenesis and the pathophysiological mechanisms of epileptogenesis in this group of developmental disorders. Both emerging neuropathological and basic science evidence will be analyzed, highlighting the involvement of different, but often converging, pathogenetic and epileptogenic mechanisms, which may create the basis for new therapeutic strategies in these disorders.Electronic supplementary material: The online version of this article (doi:10.1007/s13311-013-0251-0) contains supplementary material, which is available to authorized users. Twit Text FOAVip Epilepsy Related to Developmental Tumors and Malformations of Cortical Development ????Neurotherapeutics http://www.kidney.de/pget.php?&tw=1&pmid=24481729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24481729 #FOAvip English Wikipedia <ref>{{Cite pmid|24481729}}</ref> Epilepsy Related to Developmental Tumors and Malformations of Cortical Development #MMPMID24481729 Aronica E; Crino PB Neurotherapeutics 2014[Apr]; 11 (2): 251-68 PMID24481729show ga Structural abnormalities of the brain are increasingly recognized in patients with neurodevelopmental delay and intractable focal epilepsies. The access to clinically well-characterized neurosurgical material has provided a unique opportunity to better define the neuropathological, neurochemical, and molecular features of epilepsy-associated focal developmental lesions. These studies help to further understand the epileptogenic mechanisms of these lesions. Neuropathological evaluation of surgical specimens from patients with epilepsy-associated developmental lesions reveals two major pathologies: focal cortical dysplasia and low-grade developmental tumors (glioneuronal tumors). In the last few years there have been major advances in the recognition of a wide spectrum of developmental lesions associated with a intractable epilepsy, including cortical tubers in patients with tuberous sclerosis complex and hemimegalencephaly. As an increasing number of entities are identified, the development of a unified and comprehensive classification represents a great challenge and requires continuous updates. The present article reviews current knowledge of molecular pathogenesis and the pathophysiological mechanisms of epileptogenesis in this group of developmental disorders. Both emerging neuropathological and basic science evidence will be analyzed, highlighting the involvement of different, but often converging, pathogenetic and epileptogenic mechanisms, which may create the basis for new therapeutic strategies in these disorders.Electronic supplementary material: The online version of this article (doi:10.1007/s13311-013-0251-0) contains supplementary material, which is available to authorized users. äEpilepsy Related to Developmental Tumors and Malformations of Cortical(epmc).pdf DeepDyve Pubget Overpricing