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10.1007/s13311-014-0267-0 http://scihub22266oqcxt.onion/10.1007/s13311-014-0267-0 C3996114!3996114!24664660     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurotherapeutics 2014 ; 11 (2): 269-85 Nephropedia Template TP {{tp|p=24664660|t=2014. Genetic Epilepsy Syndromes Without Structural Brain Abnormalities: Clinical Features and Experimental Models |pdf=|usr=}}{{24664660}} gab.com Text Genetic Epilepsy Syndromes Without Structural Brain Abnormalities: Clinical Features and Experimental Models JO: Neurotherapeutics http://www.kidney.de/pget.php?&tw=1&pmid=24664660 #FOAvip Research in genetics of epilepsy represents an area of great interest both for clinical purposes and for understanding the basic mechanisms of epilepsy. Most mutations in epilepsies without structural brain abnormalities have been identified in ion channel genes, but an increasing number of genes involved in a diversity of functional and developmental processes are being recognized through whole exome or genome sequencing. Targeted molecular diagnosis is now available for different forms of epilepsy. The identification of epileptogenic mutations in patients before epilepsy onset and the possibility of developing therapeutic strategies tested in experimental models may facilitate experimental approaches that prevent epilepsy or decrease its severity. Functional analysis is essential for better understanding pathogenic mechanisms and gene interactions. In vitro experimental systems are either cells that usually do not express the protein of interest or neurons in primary cultures. In vivo/ex vivo systems are organisms or preparations obtained from them (e.g., brain slices), which should better model the complexity of brain circuits and actual pathophysiological conditions. Neurons differentiated from induced pluripotent stem cells generated from the skin fibroblasts of patients have recently allowed the study of mutations in human neurons having the genetic background of a given patient. However, there is remarkable complexity underlying epileptogenesis in the clinical dimension, as reflected by the fact that experimental models have not provided yet results having clinical translation and that, with a few exceptions concerning rare conditions, no new curative treatment has emerged from any genetic finding in epilepsy.Electronic supplementary material: The online version of this article (doi:10.1007/s13311-014-0267-0) contains supplementary material, which is available to authorized users. Twit Text FOAVip Genetic Epilepsy Syndromes Without Structural Brain Abnormalities: Clinical Features and Experimental Models ????Neurotherapeutics http://www.kidney.de/pget.php?&tw=1&pmid=24664660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24664660 #FOAvip English Wikipedia <ref>{{Cite pmid|24664660}}</ref> Genetic Epilepsy Syndromes Without Structural Brain Abnormalities: Clinical Features and Experimental Models #MMPMID24664660 Guerrini R; Marini C; Mantegazza M Neurotherapeutics 2014[Apr]; 11 (2): 269-85 PMID24664660show ga Research in genetics of epilepsy represents an area of great interest both for clinical purposes and for understanding the basic mechanisms of epilepsy. Most mutations in epilepsies without structural brain abnormalities have been identified in ion channel genes, but an increasing number of genes involved in a diversity of functional and developmental processes are being recognized through whole exome or genome sequencing. Targeted molecular diagnosis is now available for different forms of epilepsy. The identification of epileptogenic mutations in patients before epilepsy onset and the possibility of developing therapeutic strategies tested in experimental models may facilitate experimental approaches that prevent epilepsy or decrease its severity. Functional analysis is essential for better understanding pathogenic mechanisms and gene interactions. In vitro experimental systems are either cells that usually do not express the protein of interest or neurons in primary cultures. In vivo/ex vivo systems are organisms or preparations obtained from them (e.g., brain slices), which should better model the complexity of brain circuits and actual pathophysiological conditions. Neurons differentiated from induced pluripotent stem cells generated from the skin fibroblasts of patients have recently allowed the study of mutations in human neurons having the genetic background of a given patient. However, there is remarkable complexity underlying epileptogenesis in the clinical dimension, as reflected by the fact that experimental models have not provided yet results having clinical translation and that, with a few exceptions concerning rare conditions, no new curative treatment has emerged from any genetic finding in epilepsy.Electronic supplementary material: The online version of this article (doi:10.1007/s13311-014-0267-0) contains supplementary material, which is available to authorized users. äGenetic Epilepsy Syndromes Without Structural Brain Abnormalities: Cli(epmc).pdf DeepDyve Pubget Overpricing