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Mechanisms of Nuclear Actin in Chromatin Remodeling Complexes #MMPMID24246764
Kapoor P; Shen X
Trends Cell Biol 2014[Apr]; 24 (4): 238-46 PMID24246764show ga
The mystery of nuclear actin has puzzled biologists for decades largely due to the lack of defined experimental systems. However, the development of actin-containing chromatin modifying complexes as a defined genetic and biochemical system in the past decade has provided an unprecedented opportunity to dissect the mechanism of actin in the nucleus. While the established functions of actin mostly rely on its dynamic polymerization, the novel finding of actin's mechanism in the INO80 chromatin remodeling complex suggests a conceptually distinct mode of actin that functions as a monomer. In this review, we highlight the new paradigm and discuss how actin's interaction with chromatin suggests a fundamental divergence between conventional cytoplasmic actin and nuclear actin. Furthermore, we provide how this framework could be applied to investigations of nuclear actin in other actin-containing chromatin modifying complexes.