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10.1111/febs.12667 http://scihub22266oqcxt.onion/10.1111/febs.12667 C3991732!3991732!24393460     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+J 2014 ; 281 (8): 1965-73 Nephropedia Template TP {{tp|p=24393460|t=2014. Examining weak protein-protein interactions in start codon recognition via nuclear magnetic resonance spectroscopy |pdf=|usr=}}{{24393460}} gab.com Text Examining weak protein-protein interactions in start codon recognition via nuclear magnetic resonance spectroscopy JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=24393460 #FOAvip Weak protein-protein interactions are critical in numerous biological processes. Unfortunately, they are difficult to characterize due to the high concentrations required for the production and detection of the complex population. The inherent sensitivity of nuclear magnetic resonance (NMR) spectroscopy to the chemical environment makes it an excellent tool to tackle this problem. NMR permits the exploration of interactions over a range of affinities, yielding essential insights into dynamic biological processes. The conversion of mRNA to protein is one such process that requires the coordinated association of many low affinity proteins. During start codon recognition, eukaryotic initiation factors assemble into high-order complexes that bind mRNA and bring it to the ribosome for decoding. Many of the structures of the eukaryotic initiation factors have been determined; however, only little is known regarding the weak binary complexes formed and their structure-function mechanisms. Herein, we use start codon recognition as a model system to review the relevant NMR methods for the characterization of weak interactions and the development of small molecule inhibitors. Twit Text FOAVip Examining weak protein-protein interactions in start codon recognition via nuclear magnetic resonance spectroscopy ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=24393460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24393460 #FOAvip English Wikipedia <ref>{{Cite pmid|24393460}}</ref> Examining weak protein-protein interactions in start codon recognition via nuclear magnetic resonance spectroscopy #MMPMID24393460 Luna RE; Akabayov SR; Ziarek JJ; Wagner G FEBS J 2014[Apr]; 281 (8): 1965-73 PMID24393460show ga Weak protein-protein interactions are critical in numerous biological processes. Unfortunately, they are difficult to characterize due to the high concentrations required for the production and detection of the complex population. The inherent sensitivity of nuclear magnetic resonance (NMR) spectroscopy to the chemical environment makes it an excellent tool to tackle this problem. NMR permits the exploration of interactions over a range of affinities, yielding essential insights into dynamic biological processes. The conversion of mRNA to protein is one such process that requires the coordinated association of many low affinity proteins. During start codon recognition, eukaryotic initiation factors assemble into high-order complexes that bind mRNA and bring it to the ribosome for decoding. Many of the structures of the eukaryotic initiation factors have been determined; however, only little is known regarding the weak binary complexes formed and their structure-function mechanisms. Herein, we use start codon recognition as a model system to review the relevant NMR methods for the characterization of weak interactions and the development of small molecule inhibitors. äExamining weak protein-protein interactions in start codon recognition(epmc).pdf DeepDyve Pubget Overpricing